Characterizing cognitive aging of recognition memory and related processes in animal models and in humans

被引：51
作者：
Burke, Sara N. [1 ,2 ]
Ryan, Lee [1 ,3 ,4 ]
Barnes, Carol A. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Arizona, Evelyn F McKnight Brain Inst, Tucson, AZ 85724 USA
[2] Univ Arizona, ARL Div Neural Syst, Tucson, AZ 85724 USA
[3] Univ Arizona, Dept Psychol, Tucson, AZ 85724 USA
[4] Univ Arizona, Dept Neurol, Tucson, AZ 85724 USA
来源：
FRONTIERS IN AGING NEUROSCIENCE | 2012年 / 4卷
关键词：
medial temporal lobe; monkey; perception; perirhinal cortex; rat; MEDIAL TEMPORAL-LOBE; NONMATCHING-TO-SAMPLE; RESOLVES FEATURE AMBIGUITY; AGED RHESUS-MONKEYS; PERIRHINAL CORTEX; OBJECT-RECOGNITION; NEUROTOXIC LESIONS; VISUAL RECOGNITION; FORNIX TRANSECTION; WORKING-MEMORY;
D O I：
10.3389/fnagi.2012.00015
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Analyses of complex behaviors across the lifespan of animals can reveal the brain regions that are impacted by the normal aging process, thereby, elucidating potential therapeutic targets. Recent data from rats, monkeys, and humans converge, all indicating that recognition memory and complex visual perception are impaired in advanced age. These cognitive processes are also disrupted in animals with lesions of the perirhinal cortex, indicating that the the functional integrity of this structure is disrupted in old age. This current review summarizes these data, and highlights current methodologies for assessing perirhinal cortex-dependent behaviors across the lifespan.
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页数：13
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