Minimal contribution of Vα14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice

被引：38

作者：

Kawakami, K

Kinjo, Y

Uezu, K

Yara, S

Miyagi, K

Koguchi, Y

Nakayama, T

Taniguchi, M

Saito, A

机构：

[1] Univ Ryukyus, Fac Med, Dept Internal Med 1, Nishihara, Okinawa 9030215, Japan

[2] Chiba Univ, Grad Sch Med, Dept Mol Immunol, CREST Project, Chiba 2608670, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2002年 / 46卷 / 03期

关键词：

NKT cells; Th1; response; host defense; mycobacterial infection;

D O I：

10.1111/j.1348-0421.2002.tb02687.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We elucidated the contribution of Valpha14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Valpha14 NKT cell-deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild-type mice after pulmonary infection. There was no significant difference in the lung concentrations of IFN-gamma between the two strains of mice. In addition, host defense to systemic infection with M. tuberculosis was similar to that of M. bovis. Our results indicate that Valpha14 NKT cells play only a marginal role, if any, in the Th1 response and host resistance to mycobacterial infection.

引用

页码：207 / 210

页数：4

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