Regulation of iron homeostasis by microRNAs

被引：19
作者：
Castoldi, Mirco [1 ,2 ]
Muckenthaler, Martina U. [1 ,2 ]
机构：
[1] Heidelberg Univ, Dept Pediat Hematol Oncol & Immunol, D-69120 Heidelberg, Germany
[2] Heidelberg Univ, Mol Med Partnership Unit, D-69120 Heidelberg, Germany
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2012年 / 69卷 / 23期
关键词：
Iron homeostasis; MicroRNA; MESSENGER-RNAS; MOUSE MODEL; DOWN-REGULATION; HEPCIDIN; METABOLISM; EXPRESSION; GENE; BINDING; DGCR8; CELLS;
D O I：
10.1007/s00018-012-1031-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Iron homeostasis is maintained at the cellular and systemic levels to assure adequate iron supply while preventing iron overload. The identification of genes mutated in patients with iron-related disorders or animal models with imbalances of iron homeostasis gave insight into the molecular mechanisms underlying processes critical for balancing iron levels, such as iron uptake, storage, export, and monitoring of available iron. MicroRNAs control genes involved in some of these processes adding an additional level of complexity to the regulation of iron metabolism. This review summarizes recent advances how miRNAs regulate iron homeostasis.
引用
收藏
页码：3945 / 3952
页数：8
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