Differential complexing by cyclodextrin twin-cavity hosts

被引：7

作者：

Brady, B ^{[1
]}

Darcy, R ^{[1
]}

O'Sullivan, JF ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Dublin, Lab Carbohydrate & Mol Recognit Chem, Dublin 4, Ireland

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 1999年 / 33卷 / 01期

关键词：

beta-cyclodextrin dimer; clofazimine complex; methyl orange complex; association constant;

D O I：

10.1023/A:1008063509266

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The twin-cavity cyclodextrin (1) in which the link is a dithiotrehalosyl unit, and the flexibly-linked dimer (2) were shown to distinguish between the heterocyclic guests 3 and 4 (clofazimine drug) in spite of the guests' small structural difference. Both cyclodextrin dimer hosts form 1:1 complexes with methyl orange and with 3, as shown by double reciprocal plots of UV-absorbance change and host concentration. However with 4, both host molecules formed a 2:1 (host:guest) complex. Since both dimer cavities are used to create this effect, it is a new type of selectivity for macrocyclic hosts.

引用

页码：39 / 46

页数：8

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