The interaction of menaquinone-4 with phospholipid membranes

被引：0
|
作者：
Asai, Y [1 ]
Watanabe, S
机构：
[1] Eisai Co Ltd, Formulat Res Lab, Kawashima, Gifu 5016195, Japan
[2] Eisai Co Ltd, Tsukuba Res Labs, Ibaraki, Osaka 3002635, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1999年 / 47卷 / 05期
关键词：
menaquinone-4; dipalmitoylphosphatidylcholine; monolayer-bilayer equilibrium; solubility; phase transition;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effects of menaquinone-4 (MQ) on dipalmitoylphosphatidylcholine (DPPC) membranes were studied by surface monolayer and fluorescence techniques, DPPC and MQ have been proven to be freely miscible in the mixed monolayer at an air/water interface, and to be partially miscible in a bulk phase, i.e., the bilayer and solid phase, There is an expanding interaction between MQ and DPPC in the MQ/DPPC mixed monolayers, The solubility of MQ in the DPPC is about 20 mol%, and the solubility of DPPC in MQ is about 10 mol%, The addition of MQ induced a proportional decrease in the phase transition temperature of DPPC membrane and a broadening of the temperature range of the transition.
引用
收藏
页码：702 / 704
页数：3
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