Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets

被引：23

作者：

Hudson, Sean A. ^{[1
]}

McLean, Kirsty J. ^{[2
]}

Munro, Andrew W. ^{[2
]}

Abell, Chris ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Manchester, Manchester Interdisciplinary Bioctr, Fac Life Sci, Manchester M1 7DN, Lancs, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2012年 / 40卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

cytochrome P450; drug discovery; fragment-based drug discovery; high-throughput screening (HTS); Mycobacterium tuberculosis; tuberculosis; AZOLE ANTIFUNGALS; IN-VITRO; P450; INHIBITORS; CYP51; IDENTIFICATION; MONOOXYGENASE; CYP121; GROWTH; AGENTS;

D O I：

10.1042/BST20120062

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TB (tuberculosis) disease remains responsible for the death of over 1.5 million people each year. The alarming emergence of drug-resistant TB has sparked a critical need for new front-line TB drugs with a novel mode of action. In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns that are being used to probe their potential druggability.

引用

页码：573 / 579

页数：7

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