Targeting Epigenetic Readers in Cancer

被引：305
作者：
Dawson, Mark A. [1 ,2 ,3 ,4 ]
Kouzarides, Tony [3 ,4 ]
Huntly, Brian J. P. [1 ,2 ,5 ]
机构：
[1] Univ Cambridge, Dept Haematol, Cambridge Inst Med Res, Cambridge CB2 0XY, England
[2] Univ Cambridge, Cambridge Univ Hosp Natl Hlth Serv Fdn Trust, Cambridge CB2 0XY, England
[3] Univ Cambridge, Gurdon Inst, Cambridge CB2 0XY, England
[4] Univ Cambridge, Dept Pathol, Cambridge CB2 0XY, England
[5] Univ Cambridge, Wellcome Trust & Med Res Council, Cambridge Stem Cell Inst, Cambridge CB2 0XY, England
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2012年 / 367卷 / 07期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
BROMODOMAIN PROTEIN BRD4; FRAGMENT-BASED DISCOVERY; ACUTE MYELOID-LEUKEMIA; HISTONE H3; TRANSCRIPTIONAL REGULATION; CHROMATIN MODIFICATIONS; MOLECULAR-MECHANISM; MULTIPLE-MYELOMA; DRUG-SENSITIVITY; BET BROMODOMAINS;
D O I：
10.1056/NEJMra1112635
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：647 / 657
页数：11
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