Targeting Epigenetic Readers in Cancer

被引：300
作者：
Dawson, Mark A. [1 ,2 ,3 ,4 ]
Kouzarides, Tony [3 ,4 ]
Huntly, Brian J. P. [1 ,2 ,5 ]
机构：
[1] Univ Cambridge, Dept Haematol, Cambridge Inst Med Res, Cambridge CB2 0XY, England
[2] Univ Cambridge, Cambridge Univ Hosp Natl Hlth Serv Fdn Trust, Cambridge CB2 0XY, England
[3] Univ Cambridge, Gurdon Inst, Cambridge CB2 0XY, England
[4] Univ Cambridge, Dept Pathol, Cambridge CB2 0XY, England
[5] Univ Cambridge, Wellcome Trust & Med Res Council, Cambridge Stem Cell Inst, Cambridge CB2 0XY, England
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2012年 / 367卷 / 07期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
BROMODOMAIN PROTEIN BRD4; FRAGMENT-BASED DISCOVERY; ACUTE MYELOID-LEUKEMIA; HISTONE H3; TRANSCRIPTIONAL REGULATION; CHROMATIN MODIFICATIONS; MOLECULAR-MECHANISM; MULTIPLE-MYELOMA; DRUG-SENSITIVITY; BET BROMODOMAINS;
D O I：
10.1056/NEJMra1112635
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：647 / 657
页数：11
相关论文
共 60 条
  • [1] Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides
    Bamborough, Paul
    Diallo, Hawa
    Goodacre, Jonathan D.
    Gordon, Laurie
    Lewis, Antonia
    Seal, Jonathan T.
    Wilson, David M.
    Woodrow, Michael D.
    Chung, Chun-wa
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (02) : 587 - 596
  • [2] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    Bannister, AJ
    Zegerman, P
    Partridge, JF
    Miska, EA
    Thomas, JO
    Allshire, RC
    Kouzarides, T
    [J]. NATURE, 2001, 410 (6824) : 120 - 124
  • [3] Regulation of chromatin by histone modifications
    Bannister, Andrew J.
    Kouzarides, Tony
    [J]. CELL RESEARCH, 2011, 21 (03) : 381 - 395
  • [4] The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    Barretina, Jordi
    Caponigro, Giordano
    Stransky, Nicolas
    Venkatesan, Kavitha
    Margolin, Adam A.
    Kim, Sungjoon
    Wilson, Christopher J.
    Lehar, Joseph
    Kryukov, Gregory V.
    Sonkin, Dmitriy
    Reddy, Anupama
    Liu, Manway
    Murray, Lauren
    Berger, Michael F.
    Monahan, John E.
    Morais, Paula
    Meltzer, Jodi
    Korejwa, Adam
    Jane-Valbuena, Judit
    Mapa, Felipa A.
    Thibault, Joseph
    Bric-Furlong, Eva
    Raman, Pichai
    Shipway, Aaron
    Engels, Ingo H.
    Cheng, Jill
    Yu, Guoying K.
    Yu, Jianjun
    Aspesi, Peter, Jr.
    de Silva, Melanie
    Jagtap, Kalpana
    Jones, Michael D.
    Wang, Li
    Hatton, Charles
    Palescandolo, Emanuele
    Gupta, Supriya
    Mahan, Scott
    Sougnez, Carrie
    Onofrio, Robert C.
    Liefeld, Ted
    MacConaill, Laura
    Winckler, Wendy
    Reich, Michael
    Li, Nanxin
    Mesirov, Jill P.
    Gabriel, Stacey B.
    Getz, Gad
    Ardlie, Kristin
    Chan, Vivien
    Myer, Vic E.
    [J]. NATURE, 2012, 483 (7391) : 603 - 607
  • [5] High-resolution profiling of histone methylations in the human genome
    Barski, Artern
    Cuddapah, Suresh
    Cui, Kairong
    Roh, Tae-Young
    Schones, Dustin E.
    Wang, Zhibin
    Wei, Gang
    Chepelev, Iouri
    Zhao, Keji
    [J]. CELL, 2007, 129 (04) : 823 - 837
  • [6] A decade of exploring the cancer epigenome - biological and translational implications
    Baylin, Stephen B.
    Jones, Peter A.
    [J]. NATURE REVIEWS CANCER, 2011, 11 (10) : 726 - 734
  • [7] An operational definition of epigenetics
    Berger, Shelley L.
    Kouzarides, Tony
    Shiekhattar, Ramin
    Shilatifard, Ali
    [J]. GENES & DEVELOPMENT, 2009, 23 (07) : 781 - 783
  • [8] Caparros, 2007, EPIGENETICS
  • [9] Initial genome sequencing and analysis of multiple myeloma
    Chapman, Michael A.
    Lawrence, Michael S.
    Keats, Jonathan J.
    Cibulskis, Kristian
    Sougnez, Carrie
    Schinzel, Anna C.
    Harview, Christina L.
    Brunet, Jean-Philippe
    Ahmann, Gregory J.
    Adli, Mazhar
    Anderson, Kenneth C.
    Ardlie, Kristin G.
    Auclair, Daniel
    Baker, Angela
    Bergsagel, P. Leif
    Bernstein, Bradley E.
    Drier, Yotam
    Fonseca, Rafael
    Gabriel, Stacey B.
    Hofmeister, Craig C.
    Jagannath, Sundar
    Jakubowiak, Andrzej J.
    Krishnan, Amrita
    Levy, Joan
    Liefeld, Ted
    Lonial, Sagar
    Mahan, Scott
    Mfuko, Bunmi
    Monti, Stefano
    Perkins, Louise M.
    Onofrio, Robb
    Pugh, Trevor J.
    Rajkumar, S. Vincent
    Ramos, Alex H.
    Siegel, David S.
    Sivachenko, Andrey
    Stewart, A. Keith
    Trudel, Suzanne
    Vij, Ravi
    Voet, Douglas
    Winckler, Wendy
    Zimmerman, Todd
    Carpten, John
    Trent, Jeff
    Hahn, William C.
    Garraway, Levi A.
    Meyerson, Matthew
    Lander, Eric S.
    Getz, Gad
    Golub, Todd R.
    [J]. NATURE, 2011, 471 (7339) : 467 - 472
  • [10] EPIGENETICS AND GENETICS Leukaemogenesis: more than mutant genes
    Chen, Jianjun
    Odenike, Olatoyosi
    Rowley, Janet D.
    [J]. NATURE REVIEWS CANCER, 2010, 10 (01) : 23 - 36
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