Isolation, synthesis, and anti-tumor activities of a novel class of podocarpic diterpenes

被引：36

作者：

Yi, XO

Wang, KW

Pan, HX ^{[1
]}

Tu, J

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

[2] Zhejiang Univ, Coll Anim Sci, Hangzhou 310027, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 04期

基金：

中国国家自然科学基金;

关键词：

diterpene; isolation; synthesis; anti-tumor activity;

D O I：

10.1016/j.bmcl.2005.11.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel unusual 17-carbon diterpenoid, named (+)-7-deoxynimbidiol, was isolated from the stalks of Celastrus hypoleucus (Oliv.) Warb. Its racemate and derivatives were synthesized, and the inhibitory activities of these compounds against four cultured human-tumor cell lines were evaluated. The structure-activity relationship was discussed. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：786 / 789

页数：4

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