Apoptosis signalling is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditions

被引：48

作者：

Argiles, Josep A. ^{[1
]}

Lopez-Soriano, Francisco J. ^{[1
]}

Busquets, Silvia ^{[1
]}

机构：

[1] Univ Barcelona, Fac Biol, Canc Res Grp, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2008年 / 40卷 / 09期

关键词：

ubiquitin-proteasome proteolytic system; muscle wasting; apoptosis; proteolysis; PI3K; UPC3; caspase-3;

D O I：

10.1016/j.biocel.2008.02.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activation of skeletal muscle proteolysis leads to wasting in many types of catabolic/chronic diseases, Protein breakdown is basically accomplished by the activation of the ubiquitin-proteasome system. Interestingly, several publications have shown that DNA fragmentation also occurs in skeletal muscle tissue during catabolism. The present review suggests that activation of apoptosis precedes protein breakdown associated with muscle wasting. In addition, the role of the different proteolytic systems and their relation with apoptosis is emphasized. Altogether, the data presented could be used for the design of new approaches for the treatment of muscle wasting diseases. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1674 / 1678

页数：5

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