Apoptosis signalling is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditions

被引:47
作者
Argiles, Josep A. [1 ]
Lopez-Soriano, Francisco J. [1 ]
Busquets, Silvia [1 ]
机构
[1] Univ Barcelona, Fac Biol, Canc Res Grp, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain
关键词
ubiquitin-proteasome proteolytic system; muscle wasting; apoptosis; proteolysis; PI3K; UPC3; caspase-3;
D O I
10.1016/j.biocel.2008.02.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Activation of skeletal muscle proteolysis leads to wasting in many types of catabolic/chronic diseases, Protein breakdown is basically accomplished by the activation of the ubiquitin-proteasome system. Interestingly, several publications have shown that DNA fragmentation also occurs in skeletal muscle tissue during catabolism. The present review suggests that activation of apoptosis precedes protein breakdown associated with muscle wasting. In addition, the role of the different proteolytic systems and their relation with apoptosis is emphasized. Altogether, the data presented could be used for the design of new approaches for the treatment of muscle wasting diseases. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1674 / 1678
页数:5
相关论文
共 20 条
[1]   Targets in clinical oncology:: the metabolic environment of the patient [J].
Argiles, Josep M. ;
Busquets, Silvia ;
Moore-Carrasco, Rodrigo ;
Figueras, Maite ;
Almendro, Vanessa ;
Lopez-Soriano, Francisco J. .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2007, 12 :3024-3051
[2]  
Argilés JM, 2006, CANC TREAT, V130, P199
[3]   TNF-α-mediated cardiomyocyte apoptosis involves caspase-12 and calpain [J].
Bajaj, Gagan ;
Sharma, Rajendra K. .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 345 (04) :1558-1564
[4]   Adult neuron survival strategies - Slamming on the brakes [J].
Benn, SC ;
Woolf, CJ .
NATURE REVIEWS NEUROSCIENCE, 2004, 5 (09) :686-700
[5]   Overexpression of UCP3 in both murine and human myotubes is linked with the activation of proteolytic systems:: A role in muscle wasting? [J].
Busquets, S ;
Garcia-Martínez, C ;
Olivan, M ;
Barreiro, E ;
López-Soriano, FJ ;
Argilés, JM .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, 1760 (02) :253-258
[6]   Anticachectic effects of formoterol:: A drug for potential treatment of muscle wasting [J].
Busquets, S ;
Figueras, MT ;
Fuster, G ;
Almendro, V ;
Moore-Carrasco, R ;
Ametller, E ;
Argilés, JM ;
López-Soriano, FJ .
CANCER RESEARCH, 2004, 64 (18) :6725-6731
[7]   Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients [J].
Busquets, Silvia ;
Deans, Chris ;
Figueras, Maite ;
Moore-Carrasco, Rodrigo ;
Lopez-Soriano, Francisco J. ;
Fearon, Kenneth C. H. ;
Argiles, Josep M. .
CLINICAL NUTRITION, 2007, 26 (05) :614-618
[8]   Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats [J].
Carbo, N. ;
Lopez-Soriano, J. ;
Costelli, P. ;
Busquets, S. ;
Alvarez, B. ;
Baccino, F. M. ;
Quinn, L. S. ;
Lopez-Soriano, F. J. ;
Argiles, J. M. .
BRITISH JOURNAL OF CANCER, 2000, 83 (04) :526-531
[9]   Ca2+-dependent proteolysis in muscle wasting [J].
Costelli, P ;
Reffo, P ;
Penna, F ;
Autelli, R ;
Bonelli, G ;
Baccino, FA .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (10) :2134-2146
[10]   Uncoupling protein-3 sensitizes cells to mitochondrial-dependent stimulus of apoptosis [J].
Dejean, L ;
Cámara, Y ;
Sibille, R ;
Solanes, G ;
Villarroya, F .
JOURNAL OF CELLULAR PHYSIOLOGY, 2004, 201 (02) :294-304