A New Alkaloid from the Seeds of Sophora alopecuroides L.

被引：14

作者：

Gao, Hong-Ying ^{[1
,2
]}

Li, Guo-Yu ^{[1
]}

Wang, Jin-Hui ^{[1
,2
,3
]}

机构：

[1] Shihezi Univ, Sch Pharm, Shihezi 832002, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med 49, Shenyang 110016, Peoples R China

[3] TCM, Key Lab Phytomed Resources & Modernizat, Shihezi 832002, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2012年 / 95卷 / 07期

关键词：

Sophora alopecuroides; Alkaloids; Alopecurin A; X-Ray crystallography; CAPILLARY-ELECTROPHORESIS; QUINOLIZIDINE ALKALOIDS;

D O I：

10.1002/hlca.201100454

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alopecurin A, an alkaloid with an unprecedented skeleton, was isolated from the seeds of Sophora alopecuroides L. The absolute configuration and structure of this compound was identified as (3S,12R)-3-hydroxy-1,7-diazatricyclo[10.4.0.13,7]heptadecane-11,16,17-trione (=(7S,15aR)-decahydro-7-hydroxy-6H-7,11-methano-4H-pyrido[1,2-a][1,7]diazacyclododecine-4,15,16(12H)-trione). The structure and absolute configuration was elucidated by spectroscopic methods, mainly HR-ESI-TOF-MS, IR, 1D-NMR (1H- and 13C-NMR), 2D-NMR (COSY, NOESY, HSQC, HMBC), and particularly X-ray crystal-diffraction and CD spectral analysis.

引用

页码：1108 / 1113

页数：6

共 10 条

[1] New norditerpenoid alkaloids from Aconitum falconeri [J].

Atta-ur-Rahman ;

Fatima, N ;

Akhtar, F ;

Choudhary, MI ;

Khalid, A .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (10) :1393-1395

[2] Studies on the dynamic accumulations of Sophora alopecuroides L. Alkaloids in different harvest times and the appropriate harvest time [J].

Gao, Hong-ying ;

Li, Guo-yu ;

Wang, Jin-hui .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2011, 879 (15-16) :1121-1125

[3] (-)-5-ALPHA-HYDROXYSOPHOCARPINE, A NEW LUPIN ALKALOID FROM THE SEEDS OF SOPHORA-FLAVESCENS VAR ANGUSTIFOLIA [J].

SAITO, K ;

ARAI, N ;

SEKINE, T ;

OHMIYA, S ;

KUBO, H ;

OTOMASU, H ;

MURAKOSHI, I .

PLANTA MEDICA, 1990, 56 (05) :487-488

[4]

Sheldrick G.M., 1997, Programs for Crystal Structure Analysis (Release 97-2)

[5]

Sheldrick G. M., 1997, SHELXL-97, Programs for Crystal Structure Analysis

[6] Determination of quinolizidine alkaloids in traditional Chinese herbal drugs by nonaqueous capillary electrophoresis [J].

Song, JZ ;

Xu, HX ;

Tian, SJ ;

But, PPH .

JOURNAL OF CHROMATOGRAPHY A, 1999, 857 (1-2) :303-311

[7]

Wu L. J., 2007, PRACTICAL NATURAL OR, V1, P318

[8]

Xiao P, 1996, CHEM PHARM BULL, V44, P1951, DOI 10.1248/cpb.44.1951

[9] Determination of quinolizidine alkaloids in Sophora medicinal plants by capillary electrophoresis [J].

Yu, YQ ;

Ding, PL ;

Chen, DF .

ANALYTICA CHIMICA ACTA, 2004, 523 (01) :15-20

[10]

李凡, 1997, 白求恩医科大学学报, V23, P603

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