Genome Evolution Analysis of Recurrent Testicular Malignant Mesothelioma by Whole-Genome Sequencing

被引：16

作者：

Zhang, Shigeng ^{[1
]}

Zhang, Qi ^{[2
]}

Sun, Qing ^{[3
]}

Tang, Jinlong ^{[4
]}

Chen, Jimin ^{[1
]}

Ji, Na ^{[5
]}

Zheng, Yichun ^{[1
]}

Fang, Francia ^{[6
]}

Lei, Wanjun ^{[7
]}

Li, Pengpeng ^{[7
]}

Zhang, Nan ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Surg Urol, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Hepatobiliary & Pancreat Surg, Hangzhou, Zhejiang, Peoples R China

[3] Jilin Med Univ, Affiliated Hosp, Dept Nutr, Jilin, Jilin, Peoples R China

[4] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pathol, Hangzhou, Zhejiang, Peoples R China

[5] Zhejiang Univ, Affiliated Hosp 2, Dept Anesthesiol, Sch Med, Hangzhou, Zhejiang, Peoples R China

[6] Duke Univ, Trinity Coll Arts & Sci, Durham, NC USA

[7] Beijing Novogene Bioinformat Technol Co Ltd, Beijing, Peoples R China

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2018年 / 45卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Mutational landscape; Tunica vaginalis testis; Whole-genome sequencing; Tumor heterogeneity; Clonal evolution; CANCER GENOME; PROTEIN; IDENTIFICATION; LANDSCAPES; RESISTANCE; MUTATIONS; AHNAK;

D O I：

10.1159/000486355

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Background/Aims: Malignant mesothelioma of the tunica vaginalis testis is a rare and lethal disease. The genomic characteristics and genetic changes of tumor cells during the progression of this disease are unknown. Methods: we performed whole-genome sequencing of four successive tumor samples derived from surgery and a blood sample in a single patient. Results: All tumors were found to have significant C-to-T and T-to-C mutations, and amplification of copy number in chromosomes 1 and 12 were notified in all tumor samples. Subclone analysis revealed a parallel evolution of the tumor in this patient. We also identified some mutations in mesothelioma-associated genes such as KIF25, AHNAK, and PRDM2. Conclusions: The results showed a comprehensive genomic change in malignant mesothelioma of the tunica vaginalis testis and provide a better understanding of the clonal evolution during tumor recurrence and metastasis. (C) 2018 The Author(s) Published by S. Karger AG, Basel

引用

页码：163 / 174

页数：12

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