Effect of Remineralization Agents on White Spot Lesions: A Systematic Review

被引：4

作者：

Rajendran, Ratheesh ^{[1
]}

Hussain, M. Sadique ^{[2
]}

Sandhya, Raghu ^{[1
]}

Ashik, Mohammed ^{[3
]}

Thomas, Arun Jacob ^{[4
]}

Mammen, Reni Elizabeth ^{[5
]}

机构：

[1] Saveetha Univ, Saveetha Dent Coll, Saveetha Inst Med & Tech Sci, Dept Conservat Dent & Endodont, Chennai, Tamil Nadu, India

[2] Noorul Islam Coll Dent Sci, Dept Oral & Maxillofacial Surg, Thiruvananthapuram, Kerala, India

[3] KMCT Dent Coll, Dept Conservat Dent & Endodont, Kozhikode, Kerala, India

[4] Noorul Islam Coll Dent Sci, Dept Oral Pathol & Microbiol, Thiruvananthapuram, Kerala, India

[5] SCB Dent Coll, Dept Prosthodont & Crown & Bridge, Cuttack, Odisha, India

来源：

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES | 2022年 / 14卷

关键词：

Casein phosphopeptide-amorphous calcium phosphate; DIAGNOdent; Ekstrand criteria; postorthodontic white spot lesions; remineralization; sodium fluoride; MI PASTE PLUS; CASEIN PHOSPHOPEPTIDE; ORTHODONTIC TREATMENT; FLUORIDE VARNISH; CPP-ACP; CARIES;

D O I：

10.4103/jpbs.jpbs_836_21

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Objective: The goal of this systematic review was to evaluate the therapeutic efficacy of Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP) remineralizing potential to that of other remineralizing treatments and placebo in both naturally occurring and postorthodontic white spot lesions (WSL) in vivo. Materials and Methods: From 2005 to 2020, the literature search used electronic databases PubMed, Embase, Science Direct, and Google Scholar to find studies published solely in English and randomized controlled trials (RCTs) employing CPP-ACP as an intervention. All eligible studies were reviewed by two independent reviewers. Results: Excluding duplications, 72 articles were identified. Abstracts of 58 articles were reviewed independently, 19 articles were excluded, 36 full text articles were retrieved; finally selecting 14 studies. Conclusion: The CPP-ACP was found to have efficacious remineralizing potential on naturally occurring and postorthodontic WSL compared to placebo or other preventive measures. Further well-performed RCTs are needed to determine the therapeutic significance of remineralizing medicines, and long-term follow-ups are required.

引用

页码：7 / 12

页数：6

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