Animal models of respiratory syncytial virus infection and disease

被引：30
|
作者：
Sacco, Randy E. [1 ]
Durbin, Russell K. [2 ]
Durbin, Joan E. [2 ,3 ]
机构：
[1] Agr Res Serv, Ruminant Dis & Immunol Res Unit, Natl Anim Dis Ctr, USDA, Ames, IA 50011 USA
[2] Rutgers State Univ, Ctr Immun & Inflammat, Newark, NJ 07102 USA
[3] Rutgers State Univ, Dept Pathol, Newark, NJ 07102 USA
来源：
CURRENT OPINION IN VIROLOGY | 2015年 / 13卷
基金：
美国国家卫生研究院;
关键词：
NONSTRUCTURAL PROTEINS NS1; MOUSE MODEL; VIRAL BRONCHIOLITIS; T-LYMPHOCYTES; COTTON RATS; CALVES; EXPRESSION; PATHOGENESIS; CHALLENGE; CELLS;
D O I：
10.1016/j.coviro.2015.06.003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The study of human respiratory syncytial virus pathogenesis and immunity has been hampered by its exquisite host specificity, and the difficulties encountered in adapting this virus to a nnurine host. The reasons for this obstacle are not well understood, but appear to reflect, at least in part, the inability of the virus to block the interferon response in any but the human host. This review addresses some of the issues encountered in mouse models of respiratory syncytial virus infection, and describes the advantages and disadvantages of alternative model systems.
引用
收藏
页码：117 / 122
页数：6
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