Adiponectin: A biomarker for chronic hepatitis C?

被引：7

作者：

Liu, Ding ^{[1
]}

Li, Shengyu ^{[2
]}

Li, Zhihong ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Dept Orthopaed, Changsha, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Dept Gen Surg, Changsha, Hunan, Peoples R China

来源：

CYTOKINE | 2017年 / 89卷

基金：

中国国家自然科学基金;

关键词：

Adiponectin; Chronic hepatitis C; Biomarker; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; PLASMA ADIPONECTIN; METABOLIC SYNDROME; T-CADHERIN; HEPATOCELLULAR-CARCINOMA; FIBROSIS PROGRESSION; SERUM ADIPONECTIN; ADIPOSE-TISSUE; NONALCOHOLIC STEATOHEPATITIS;

D O I：

10.1016/j.cyto.2015.10.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adiponectin, a hormone primarily synthesized and secreted by adipose tissue, plays a pivotal role in lipid metabolism. Chronic hepatitis C (CHC) infection is characterized by disordered lipid metabolism, which may potentially evolve into steatosis over a period of time. A growing body of evidence appears to link decreased adiponectin plasma levels with severe CHC-related steatosis, which suggests a potential role of this adipokine as a diagnostic and therapeutic target for clinical application. In this review, we have attempted to summarize the current status of adiponectin research in the context of CHC, concentrating predominantly on its roles in CHC, and its potential relevance as a biomarker for CHC. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：27 / 33

页数：7

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