Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells

被引：0
|
作者：
Terao, Y [1 ]
Kawabata, S [1 ]
Kunitomo, E [1 ]
Nakagawa, I [1 ]
Hamada, S [1 ]
机构：
[1] Osaka Univ, Fac Dent, Dept Oral Microbiol, Suita, Osaka 5650871, Japan
来源：
INFECTION AND IMMUNITY | 2002年 / 70卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The lbp gene, which encodes a laminin-binding protein (Lbp) of Streptococcus pyogenes, was found in all S. pyogenes M types. An Lbp-deficient mutant showed a significant, lower efficiency of adhesion to HEp-2 cells than did the wild-type strain. These results indicate that Lbp is one of the important S. pyogenes adhesins.
引用
收藏
页码：993 / 997
页数：5
相关论文
共 50 条
  • [21] Laminin-binding protein of Streptococcus suis serotype 2 influences zinc acquisition and cytokine responses
    Payen, Servane
    Rrodriguez, Jesus Aranda
    Segura, Mariela
    Gottschalk, Marcelo
    VETERINARY RESEARCH, 2023, 54 (01) : 1
  • [22] Cloning and expression of a cDNA encoding a nonintegrin laminin-binding protein from Echinococcus granulosus with localization of the laminin-binding domain
    Zhang, LH
    Leggatt, GR
    Kalinna, BH
    Piva, TJ
    McManus, DP
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 87 (02) : 183 - 192
  • [23] The SpeB virulence factor of Streptococcus pyogenes, a multifunctional secreted and cell surface molecule with strepadhesin, laminin-binding and cysteine protease activity
    Hytönen, J
    Haataja, S
    Gerlach, D
    Podbielski, A
    Finne, J
    MOLECULAR MICROBIOLOGY, 2001, 39 (02) : 512 - 519
  • [24] LBL, A NOVEL, DEVELOPMENTALLY REGULATED, LAMININ-BINDING LECTIN
    BAO, ZZ
    MUSCHLER, J
    HORWITZ, AF
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1992, 267 (07) : 4974 - 4980
  • [25] Expression, purification, crystallization and preliminary crystallographic analysis of laminin-binding protein (Lmb) from Streptococcus agalactiae
    Ragunathan, Preethi
    Spellerberg, Barbara
    Ponnuraj, Karthe
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2009, 65 : 492 - 494
  • [26] Mapping the laminin-binding and adhesive domain of the cell surface-associated Hlp/LBP protein from Mycobacterium leprae
    de Lima, CS
    Zulianello, L
    Marques, MAD
    Kim, H
    Portugal, MI
    Antunes, SL
    Menozzi, FD
    Ottenhoff, THM
    Brennan, PJ
    Pessolani, MCV
    MICROBES AND INFECTION, 2005, 7 (9-10) : 1097 - 1109
  • [27] Ultrastructural localization of an Echinococcus granulosus laminin-binding protein
    Jones, MK
    Zhang, LH
    Gould, RJ
    McManus, DP
    PARASITOLOGY, 1999, 118 : 319 - 325
  • [28] Laminin binding protein (LBP)/p40: A novel IRS-1-Binding protein
    Klein, E
    Kotzka, J
    Knebel, B
    Lehr, S
    Udelhoven, M
    Krone, W
    Muller-Wieland, D
    DIABETES, 2000, 49 : A448 - A448
  • [29] CRANIN - A LAMININ-BINDING PROTEIN OF CELL-MEMBRANES
    SMALHEISER, NR
    SCHWARTZ, NB
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (18) : 6457 - 6461
  • [30] STREPTOCOCCUS-PYOGENES CELL-WALL PROTEIN RESPONSIBLE FOR BINDING TO PHARYNGEAL EPITHELIAL-CELLS
    TYLEWSKA, S
    HRYNIEWICZ, W
    ZENTRALBLATT FUR BAKTERIOLOGIE MIKROBIOLOGIE UND HYGIENE SERIES A-MEDICAL MICROBIOLOGY INFECTIOUS DISEASES VIROLOGY PARASITOLOGY, 1987, 265 (1-2): : 146 - 150
12345