A silver(I)-catalyzed tandem reaction of 2-alkynylbenzaldoximes with ketenes

被引：14
|
作者：
Liu, Hongliang [1 ]
Liu, Gang [1 ]
Pu, Shouzhi [1 ]
Wang, Zhiyong [2 ]
机构：
[1] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organ Chem, Nanchang 330013, Peoples R China
[2] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400044, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 17期
基金：
美国国家科学基金会;
关键词：
1,3-DIPOLAR CYCLOADDITION REACTION; ENANTIOSELECTIVE NITRONE CYCLOADDITIONS; MEDIATED ELECTROPHILIC CYCLIZATION; TRIFLATE CATALYZED REACTION; DIELS-ALDER; 3,4-DISUBSTITUTED ISOQUINOLINES; SUBSTITUTED ISOQUINOLINES; BENZODIAZEPINE-RECEPTOR; ASYMMETRIC-SYNTHESIS; CARBONYL-COMPOUNDS;
D O I：
10.1039/c3ob27427f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and unexpected reaction of 2-alkynylbenzaldoximes with ketenes in the presence of silver triflate (10 mol%) under mild conditions is discovered. This reaction proceeds through 6-endo-cyclization, [3 + 2] cycloaddition, and rearrangement, leading to isoquinoline derivatives in moderate to good yields.
引用
收藏
页码：2898 / 2902
页数：5
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