Limonoids from the fruits of Melia azedarach and their cytotoxic activities

被引：49

作者：

Akihisa, Toshihiro ^{[1
]}

Pan, Xin ^{[1
]}

Nakamura, Yasuhiro ^{[1
]}

Kikuchi, Takashi ^{[1
]}

Takahashi, Nami ^{[1
]}

Matsumoto, Masahiro ^{[1
]}

Ogihara, Eri ^{[1
]}

Fukatsu, Makoto ^{[1
]}

Koike, Kazuo ^{[2
]}

Tokuda, Harukuni ^{[3
]}

机构：

[1] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 1018308, Japan

[2] Toho Univ, Sch Pharmaceut Sci, Funabashi, Chiba 2748510, Japan

[3] Kanazawa Univ, Grad Sch Med Sci, Kanazawa, Ishikawa 9208640, Japan

来源：

PHYTOCHEMISTRY | 2013年 / 89卷

基金：

日本学术振兴会;

关键词：

Melia azedarach; Meliaceae; Fruits; Limonoids; Cytotoxic activities; Epstein-Barr virus early antigen (EBV-EA); VAR-JAPONICA-MAKINO; C-SECO LIMONOIDS; TRITERPENOIDS; TETRANORTRITERPENOIDS; INHIBITION; LEAVES; DEATH; TWIGS; SEEDS; RING;

D O I：

10.1016/j.phytochem.2013.01.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thirty-one limonoids and one tirucallane-type triterpenoid were isolated from the fruits of Melia azedarach (Meliaceae). The structures of 14 of these isolated compounds were elucidated on the basis of spectroscopic analyses and comparison with literature. All of these compounds were evaluated for. their cytotoxic activities against HL60, A549, AZ521, and SK-BR-3 human cancer cell lines. Meliarachin C (IC50 0.65 mu M) and 3-O-deacetyl-4'-demethyl-28-oxosalannin (IC50 2.8 mu M) exhibited potent cytotoxic activity against HL60 cells, and this was demonstrated mainly due to the induction of apoptosis by flow cytometry. Western blot analysis suggested that both compounds induced apoptosis via both the mitochondrial and death receptor-mediated pathways. In addition, 25 compounds were evaluated for their inhibitory effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：59 / 70

页数：12

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