Functional magnetic resonance imaging and molecular pathology at the crossroad of the management of early prostate cancer

被引:5
作者
Renard-Penna, Raphaele [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Cancel-Tassin, Geraldine [1 ,8 ]
Comperat, Eva [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ]
Roupret, Morgan [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ]
Mozer, Pierre [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Cussenot, Olivier [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ]
机构
[1] Univ Paris 06, GRC 5, ONCOTYPE URO, Paris, France
[2] Hop La Pitie Salpetriere, AP HP, Dept Urol, Paris, France
[3] Hop La Pitie Salpetriere, AP HP, Dept Pathol, Paris, France
[4] Hop La Pitie Salpetriere, AP HP, Dept Radiol, Paris, France
[5] Tenon Hosp, AP HP, Dept Urol, Paris, France
[6] Tenon Hosp, AP HP, Dept Pathol, Paris, France
[7] Tenon Hosp, AP HP, Dept Radiol, Paris, France
[8] Hop La Pitie Salpetriere, CeRePP, Paris, France
关键词
Prostate cancer; Magnetic resonance imaging; Molecular test; Biomarkers; Urine; Focal therapy; APPARENT DIFFUSION-COEFFICIENT; FOCAL THERAPY; REPEAT BIOPSY; TUMOR VOLUME; DIAGNOSIS; LOCALIZATION; METASTASIS; VALIDATION; COHORT; ADENOCARCINOMA;
D O I
10.1007/s00345-015-1570-z
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
According to recent reports from randomized studies comparing radical treatment or watchful waiting, the outcome of localized prostate cancer remains uncertain at individual level. It is especially true for the low-risk group (according D'Amico or CAPRA classifications), regarding the individual exposition to overtreatment by radical therapies or the opposite risk of under-treatment with active surveillance. In this review, we describe the available molecular predictor tests and functional MRI, as well as their potential role in the selection of the appropriate treatment for prostate cancer patients. The recent development of functional MRI imaging and clinical practice approval of molecular predictor tests for the assessment of the aggressive prostate cancer have brought new perspectives for the management of localized prostate cancer by active surveillance, focal ablative therapy or radical therapies.
引用
收藏
页码:929 / 936
页数:8
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