Molecular Aspects of Vitamin D Anticancer Activity

被引：48

作者：

Picotto, Gabriela ^{[1
]}

Liaudat, Ana C. ^{[1
]}

Bohl, Luciana ^{[1
]}

Tolosa de Talamoni, Nori ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Med, Catedra Bioquim & Biol Mol, Lab Metab Fosfocalc Dr Fernando Canas, RA-5000 Cordoba, Argentina

来源：

CANCER INVESTIGATION | 2012年 / 30卷 / 08期

关键词：

Vitamin D; Calcitriol; Cancer; Molecular mechanisms; BREAST-CANCER CELLS; D-RECEPTOR; PROSTATE-CANCER; GENE-EXPRESSION; COLON-CANCER; 1,25-DIHYDROXYVITAMIN D-3; ANTIPROLIFERATIVE ACTION; INHIBITING CASPASE; KEY MEDIATORS; CALCIUM;

D O I：

10.3109/07357907.2012.721039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Environment may influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical, and genetic studies have shown non-classic effects of vitamin D, such as its involvement in the progression of different cancers. Although vitamin D induces cellular arrest, triggers apoptotic pathways, inhibits angiogenesis, and alters cellular adhesion, the precise mechanisms of its action are still not completely established. This article will present a revision about the molecular aspects proposed to be involved in the anticancer action of calcitriol. Adequate levels of vitamin D to prevent cancer development will also be discussed.

引用

页码：604 / 614

页数：11

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