Contrasting the Glial Response to Axon Injury in the Central and Peripheral Nervous Systems

被引：175

作者：

Lutz, Amanda Brosius ^{[1
]}

Barres, Ben A. ^{[1
]}

机构：

[1] Stanford Univ, Dept Neurobiol, Stanford, CA 94110 USA

来源：

DEVELOPMENTAL CELL | 2014年 / 28卷 / 01期

关键词：

SPINAL-CORD-INJURY; CHONDROITIN SULFATE PROTEOGLYCANS; RETINAL GANGLION-CELLS; WALLERIAN DEGENERATION; SCHWANN-CELLS; REACTIVE ASTROCYTES; NEURITE OUTGROWTH; WHITE-MATTER; IN-VITRO; REGIONAL HETEROGENEITY;

D O I：

10.1016/j.devcel.2013.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Enabling axon regeneration after central nervous system (CNS) injury remains a major challenge in neurobiology. One of the major differences between the injured peripheral nervous system (PNS) and CNS is the pro- and antiregenerative responses of their glial cell populations. In addition to intrinsic qualities of the neurons themselves, glial-driven changes to the neural environment have a significant impact on regenerative outcome. This Review presents a comparison of the glial response to injury between the CNS and PNS and highlights features of the PNS glial response that, with continued study, might reveal long-sought-after keys to achieving CNS repair.

引用

页码：7 / 17

页数：11

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