No Pharmacokinetic Interaction Between HCV Protease Inhibitor MK-5172 and HCV NS5A Inhibitor MK-8742 in Healthy Volunteers

被引:0
|
作者
Yeh, Wendy W. [1 ]
Caro, Luzelena [1 ]
Huang, Xiaobi [1 ]
Mangin, Eric [1 ]
Jumes, Patricia [1 ]
Rasmussen, Scott [2 ]
Butterton, Joan R. [1 ]
机构
[1] Merck Sharp & Dohme Corp, Whitehouse Stn, NJ USA
[2] Celerion, Lincoln, NE USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
478
引用
收藏
页码:438A / 438A
页数:1
相关论文
共 50 条
  • [1] Lack of Pharmacokinetic Interaction Between HCV Protease Inhibitor MK-5172 and HCV NS5A Inhibitor Daclatasvir in Healthy Volunteers
    Yeh, Wendy W.
    Fraser, Iain P.
    Bifano, Marc
    Caro, Luzelena
    Talaty, Jennifer E.
    Guo, Zifang
    McCarthy, Jennifer M.
    Youngberg, Stephen P.
    Butterton, Joan R.
    HEPATOLOGY, 2013, 58 : 430A - 431A
  • [2] A Combination Containing MK-5172 (HCV NS3 protease inhibitor) and MK-8742 (HCV NS5A inhibitor) Demonstrates High Barrier to Resistance in HCV Replicons
    Lahser, Frederick
    Liu, Rong
    Bystol, Karin
    Xia, Ellen
    Raubertas, Richard
    Asante-Appiah, Ernest
    Howe, Anita Y.
    HEPATOLOGY, 2012, 56 : 236A - 236A
  • [3] Pharmacokinetic Interaction Between the HCV Protease Inhibitor MK-5172 and Efavirenz in Normal Healthy Volunteers
    Talaty, Jennifer E.
    Caro, Luzelena
    Yeh, Wendy W.
    Fraser, Iain P.
    Guo, Zifang
    Butterfield, Kristin
    Reitmann, Christina
    Dunnington, Katherine M.
    DeGroot, Bruce J.
    Youngberg, Stephen P.
    Butterton, Joan R.
    HEPATOLOGY, 2013, 58 : 445A - 445A
  • [4] Pharmacokinetic Interaction Between the HCV Protease Inhibitor MK-5172 and Midazolam, Pitavastatin, and Atorvastatin in Healthy Volunteers
    Caro, Luzelena
    Talaty, Jennifer E.
    Guo, Zifang
    Reitmann, Christina
    Fraser, Iain P.
    Evers, Raymond
    Swearingen, Dennis
    Yeh, Wendy W.
    Butterton, Joan R.
    HEPATOLOGY, 2013, 58 : 437A - 438A
  • [5] Pharmacokinetic Interaction Between the HCV Protease Inhibitor MK-5172 and IV and Oral Rifampin in Healthy Volunteers
    Caro, Luzelena
    Talaty, Jennifer E.
    Guo, Zifang
    Butterfield, Kristin
    Prueksaritanont, Thomayant
    Rasmussen, Scott
    Fraser, Iain P.
    Yeh, Wendy W.
    Butterton, Joan R.
    HEPATOLOGY, 2013, 58 : 446A - 447A
  • [6] Pharmacokinetics of Co-Administered HCV Protease Inhibitor MK-5172 and NS5A Inhibitor MK-8742 in Volunteers with End-Stage Renal Disease on Hemodialysis or Severe Renal Impairment Not on Hemodialysis
    Yeh, Wendy W.
    Caro, Luzelena
    Guo, Zifang
    Feng, Hwa Ping
    Davis, Henry U.
    Kozisek, Megan
    Stypinski, Daria
    Feng, Chun
    Mitchell, Carrie
    Gillespie, Anne
    Ichhpurani, Nita
    Marshall, William L.
    Lasseter, Kenneth C.
    Marbury, Thomas C.
    Butterton, Joan R.
    HEPATOLOGY, 2014, 60 : 1137A - 1137A
  • [7] Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity
    Coburn, Craig A.
    Meinke, Peter T.
    Chang, Wei
    Fandozzi, Christine M.
    Graham, Donald J.
    Hu, Bin
    Huang, Qian
    Kargman, Stacia
    Kozlowski, Joseph
    Liu, Rong
    McCauley, John A.
    Nomeir, Amin A.
    Soll, Richard M.
    Vacca, Joseph P.
    Wang, Dahai
    Wu, Hao
    Zhong, Bin
    Olsen, David B.
    Ludmerer, Steven W.
    CHEMMEDCHEM, 2013, 8 (12) : 1930 - 1940
  • [8] Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742
    Yu, Wensheng
    Coburn, Craig A.
    Nair, Anilkumar G.
    Wong, Michael
    Tong, Ling
    Dwyer, Michael P.
    Hu, Bin
    Zhong, Bin
    Hao, Jinglai
    Yang, De-Yi
    Selyutin, Oleg
    Jiang, Yueheng
    Rosenblum, Stuart B.
    Kim, Seong Heon
    Lavey, Brian J.
    Zhou, Guowei
    Rizvi, Razia
    Shankar, Bandarpalle B.
    Zeng, Qingbei
    Chen, Lei
    Agrawal, Sony
    Carr, Donna
    Rokosz, Laura
    Liu, Rong
    Curry, Stephanie
    McMonagle, Patricia
    Ingravallo, Paul
    Lahser, Fred
    Asante-Appiah, Ernest
    Nomeir, Amin
    Kozlowski, Joseph A.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (15) : 3800 - 3805
  • [9] A PHASE 1 STUDY TO EVALUATE THE INTERACTION OF HCV NS5B INHIBITOR MK-3682 WITH HCV NS3/4A PROTEASE INHIBITOR MK-5172 AND HCV NS5A INHIBITOR MK-8408 IN HEALTHY SUBJECTS
    Zhou, X. -J.
    Sicard, E.
    Chen, J.
    Frank, D.
    Gao, W.
    Rizk, M. L.
    Rhee, E. G.
    Butterton, J. R.
    Sullivan-Bolyai, J.
    JOURNAL OF HEPATOLOGY, 2015, 62 : S646 - S646
  • [10] Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742
    Yu, Wensheng
    Zhou, Guowei
    Coburn, Craig A.
    Zeng, Qingbei
    Tong, Ling
    Dwyer, Michael P.
    Hu, Bin
    Zhong, Bin
    Hao, Jinglai
    Ji, Tao
    Zan, Shuai
    Chen, Lei
    Mazzola, Robert
    Kim, Jae-Hun
    Sha, Deyou
    Selyutin, Oleg
    Rosenblum, Stuart B.
    Lavey, Brian
    Nair, Anilkumar G.
    Kim, Seong Heon
    Keertikar, Kerry M.
    Rokosz, Laura
    Agrawal, Sony
    Liu, Rong
    Xia, Ellen
    Zhai, Ying
    Curry, Stephanie
    McMonagle, Patricia
    Ingravallo, Paul
    Asante-Appiah, Ernest
    Chen, Shiying
    Kozlowski, Joseph A.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (19) : 4851 - 4856