Synthesis, structure, and cytotoxicity of complexes of zinc(II), palladium(II), and copper(I) chlorides with (-)-camphor thiosemicarbazone

被引：15

作者：

Kokina, Tatyana E. ^{[1
,2
]}

Glinskaya, Ludmila A. ^{[1
]}

Sheludyakova, Liliya A. ^{[1
,2
]}

Eremina, Yuliya A. ^{[1
,2
,3
]}

Klyushova, Lubov S. ^{[3
]}

Komarov, Vladislav Yu ^{[1
,2
]}

Piryazev, Dmitriy A. ^{[1
]}

Tkachev, Alexey, V ^{[2
,4
]}

Larionov, Stanislav, V ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Siberian Branch, Nikolaev Inst Inorgan Chem, 3 Acad Lavrentiev Ave, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, 2 Pirogov Str, Novosibirsk 630090, Russia

[3] Fed Res Ctr Fundamental & Translat Med, 2 Timakova Str, Novosibirsk 630117, Russia

[4] Russian Acad Sci, Siberian Branch, Vorozhtsov Inst Organ Chem, 9 Acad Lavrentiev Ave, Novosibirsk 630090, Russia

来源：

POLYHEDRON | 2019年 / 163卷

关键词：

Complexes; Thiosemicarbazone; Terpene; Crystal structure; Cytotoxicity; TRANSITION-METAL-COMPLEXES; CRYSTAL-STRUCTURE; ANTIMICROBIAL ACTIVITY; ESI-MASS; ANTIPROLIFERATIVE ACTIVITY; COORDINATION; SPECTROSCOPY; DNA/PROTEIN; (+)-CAMPHOR; DERIVATIVES;

D O I：

10.1016/j.poly.2019.02.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Complexes [Zn(L-2)(2)Cl-2], [Pd-2(L-2)(2)Cl-4], and (CuLCI)-C-2, where L-2 is (-)-camphor thiosemicarbazone, were synthesized. The structures of complexes [Zn(L-2)(2)Cl-2] and [Pd-2(L-2)(2)Cl-4] were determined by X-ray diffraction. The crystal structure of complex [Zn(L-2)(2)Cl-2] contains mononuclear molecules with distorted tetrahedral (ZnCl2S2) coordination units and monodentate L-2 ligands. Complex [Pd-2(L-2)(2)Cl-4] has binuclear structure with Pd metal centers linked by L-2 ligands via mu(2)-S atoms. Complex (CuLCI)-C-2, according to IR and NMR spectra contains S and Cl atoms in the coordination sphere of ion Cu+. Complexes [Pd(tsc)Cl-2] and Zn(tsc)(2)Cl-2 (where tsc is thiosemicarbazide) were also obtained to determine the influence of the terpene moiety on cytotoxic properties of these compounds. Mononuclear complex [Pd(tsc)Cl-2] contains an NSCl2 planar square coordination polyhedron, and tsc is a bidentate chelate ligand. The effects of tsc, L-2, and the complexes with tsc and L-2 on viability of the MCF-7 cell line were investigated next. The results showed that tsc and L-2 are nontoxic at the tested concentrations (1-50 mu M). All the complexes exerted a significant dose-dependent cytotoxic effect, whereas complex (CuLCI)-C-2 was found to have the lowest half-maximal inhibitory concentration (IC50). (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：121 / 130

页数：10

共 61 条

[21] PREPARATION OF SOME THIOSEMICARBAZONES AND THEIR COPPER COMPLEXES .2 [J].