Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy

被引:68
作者
Kume, Shinji [1 ]
Kitada, Munehiro [2 ]
Kanasaki, Keizo [2 ]
Maegawa, Hiroshi [1 ]
Koya, Daisuke [2 ]
机构
[1] Shiga Univ Med Sci, Dept Med, Otsu, Shiga 52021, Japan
[2] Kanazawa Med Univ, Div Diabet & Endocrinol, Uchinada, Ishikawa 9200293, Japan
关键词
Diabetic nephropathy; Sirt1; Sirtuin; Calorie restriction; Autophagy; CALORIE RESTRICTION DELAYS; CELL APOPTOSIS; ACTIVATION; EXPRESSION; PROTECTS; HYPOXIA; COMPLICATIONS; TRANSCRIPTION; RESVERATROL; SURVIVAL;
D O I
10.1007/s12272-013-0019-4
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Caloric restriction prolongs the lifespan of many species. Therefore, investigators have researched the usefulness of caloric restriction for healthy lifespan extension. Sirt1, an NAD(+)-dependent deacetylase, was identified as a molecule necessary for caloric restriction-related anti-aging strategies. Sirt1 functions as an intracellular energy sensor to detect the concentration of NAD(+), and controls in vivo metabolic changes under caloric restriction and starvation through its deacetylase activity to many targets including histones, nuclear transcriptional factors, and enzymes. During the past decade, investigators have reported the relationship between disturbance of Sirt1 activation and the onset of aging- and obesity-associated diseases such as diabetes, cardiovascular disease and neurodegenerative disorders. Consequently, a calorie restriction-mimetic action of Sirt1 is now expected as a new therapy for these diseases. In addition, recent studies have gradually clarified the role of Sirt1 in the onset of kidney disease. Its activation may also become a new target of treatment in the patients with chronic kidney disease including diabetic nephropathy. In this article, we would like to review the role of Sirt1 in the onset of kidney disease based on previous studies, and discuss its possibility as the target of treatment in diabetic nephropathy.
引用
收藏
页码:230 / 236
页数:7
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