Mitochondria in Health and Disease

被引:7
|
作者
Meiliana, Anna [1 ,2 ]
Dewi, Nurrani Mustika [2 ]
Wijaya, Andi [1 ,2 ]
机构
[1] Padjadjaran State Univ, Postgrad Program Clin Pharm, Jl Eijkman 38, Bandung, Indonesia
[2] Prodia Clin Lab, Jl Cisangkuy 2, Bandung, Indonesia
来源
INDONESIAN BIOMEDICAL JOURNAL | 2019年 / 11卷 / 01期
关键词
mitochondria; UPR; mitochondrial quality control; proteostasis; mitohormesis; mitochondrial diseases; UNFOLDED PROTEIN RESPONSE; QUALITY-CONTROL; SKELETAL-MUSCLE; STRESS-RESPONSE; OXIDATIVE-PHOSPHORYLATION; HEART-MITOCHONDRIA; IMPORT MACHINERY; GENE-EXPRESSION; OUTER-MEMBRANE; CALCIUM-IONS;
D O I
10.18585/inabj.v11i1.779
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
BACKGROUND: Mitochondrial dysfunction known to be associated with most of human inherited disorders and diseases, including neurodegenerative disorders, cardiomyopathies, metabolic syndrome, muscle weakness, cancer, also obesity. CONTENT: Mitochondria charges for multiple anabolic and catabolic circuitries, as the main provider for adenosine triphosphate (ATP). Mitochondria also responsible for cell-wide stress responses and control non-apoptotic cell death routines, such as autophagy and regulated necrosis. In other words, mitochondria play an extended role in regulating cellular functions, both vital and lethal, from physiological metabolism to stress responses and death to maintain adult tissue homeostasis. Furthermore, mitochondria are crucial for both embryonic and postembryonic development. Therefore, any defect or alteration in mitochondria signaling pathways will lead to a large number of diseases in human, including premature aging, neurodegenerative disorders, muscle weakness, cardiovascular disorders, and cancer. SUMMARY: Mitochondria perform a dynamic, integrated interconnected network, to maintain tissue homeostasis, beyond the cell boundaries and regulating cells and tissues communication. Certainly any mitochondrial dysfunction could direct to neurodegenerative diseases and metabolic disorders.
引用
收藏
页码:1 / 15
页数:15
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