Metal-Free Sulfonylation of 3,4-Dihalo-2(5H)-furanones (X = Cl, Br) with Sodium Sulfinates under Air Atmosphere in Aqueous Media via a Radical Pathway

被引：33

作者：

Cao, Liang ^{[1
]}

Li, Jian-Xiao ^{[2
]}

Wu, Han-Qing ^{[1
]}

Jiang, Kai ^{[1
]}

Hao, Zhi-Feng ^{[3
]}

Luo, Shi-He ^{[1
,2
]}

Wang, Zhao-Yang ^{[1
,2
]}

机构：

[1] South China Normal Univ, Sch Chem & Environm, Key Lab Theoret Chem Environm, Minist Educ, 378 Waihuan West Rd, Guangzhou 510006, Guangdong, Peoples R China

[2] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, 381 Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China

[3] Guangdong Univ Technol, Sch Chem Engn & Light Ind, 100 Waihuan West Rd, Guangzhou 510006, Guangdong, Peoples R China

来源：

ACS SUSTAINABLE CHEMISTRY & ENGINEERING | 2018年 / 6卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Metal-free sulfonylation; C-S bond formation; 2(5H)-furanones; Sodium sulfinates; Radical pathway; CROSS-COUPLING REACTIONS; BOND FORMATION; ROOM-TEMPERATURE; MOLECULAR-IODINE; VINYL SULFONES; ACID SALTS; SULFUR; DERIVATIVES; ACCESS; HALIDES;

D O I：

10.1021/acssuschemeng.7b04564

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient and environmentally friendly protocol has been developed for the preparation of various sulfonylated 2(5H)-furanones by the sulfonylation of C-sp2-X compounds with sodium sulfinates via a metal-free radical pathway. For low-cost C-sp2-C1 substrates, there is also a satisfactory reactivity with moderate to excellent yields as well as high atom economy. Importantly, the application of this method into a gram-scale (even over 10 g) preparation can be accomplished.

引用

页码：4147 / 4153

页数：13

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