Metal-Free Sulfonylation of 3,4-Dihalo-2(5H)-furanones (X = Cl, Br) with Sodium Sulfinates under Air Atmosphere in Aqueous Media via a Radical Pathway

被引：33
作者：
Cao, Liang [1 ]
Li, Jian-Xiao [2 ]
Wu, Han-Qing [1 ]
Jiang, Kai [1 ]
Hao, Zhi-Feng [3 ]
Luo, Shi-He [1 ,2 ]
Wang, Zhao-Yang [1 ,2 ]
机构：
[1] South China Normal Univ, Sch Chem & Environm, Key Lab Theoret Chem Environm, Minist Educ, 378 Waihuan West Rd, Guangzhou 510006, Guangdong, Peoples R China
[2] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, 381 Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China
[3] Guangdong Univ Technol, Sch Chem Engn & Light Ind, 100 Waihuan West Rd, Guangzhou 510006, Guangdong, Peoples R China
来源：
ACS SUSTAINABLE CHEMISTRY & ENGINEERING | 2018年 / 6卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Metal-free sulfonylation; C-S bond formation; 2(5H)-furanones; Sodium sulfinates; Radical pathway; CROSS-COUPLING REACTIONS; BOND FORMATION; ROOM-TEMPERATURE; MOLECULAR-IODINE; VINYL SULFONES; ACID SALTS; SULFUR; DERIVATIVES; ACCESS; HALIDES;
D O I：
10.1021/acssuschemeng.7b04564
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A convenient and environmentally friendly protocol has been developed for the preparation of various sulfonylated 2(5H)-furanones by the sulfonylation of C-sp2-X compounds with sodium sulfinates via a metal-free radical pathway. For low-cost C-sp2-C1 substrates, there is also a satisfactory reactivity with moderate to excellent yields as well as high atom economy. Importantly, the application of this method into a gram-scale (even over 10 g) preparation can be accomplished.
引用
收藏
页码：4147 / 4153
页数：13
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