Performance in real life of the European Network on Drug Allergy algorithm in immediate reactions to beta-lactam antibiotics

被引：29

作者：

Moreno, E. ^{[1
,2
,3
]}

Laffond, E. ^{[1
,2
,3
]}

Munoz-Bellido, F. ^{[1
,2
]}

Gracia, M. T. ^{[1
,2
]}

Macias, E. ^{[1
,2
]}

Moreno, A. ^{[1
]}

Davila, I. ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Salamanca, Allergy Serv, Paseo San Vicente 58-182, Salamanca 37007, Spain

[2] IBSAL Inst Biosanitario Salamanca, Salamanca, Spain

[3] Univ Salamanca, Salamanca Med Sch, Dept Biomed & Diagnost Sci, Salamanca, Spain

来源：

ALLERGY | 2016年 / 71卷 / 12期

关键词：

algorithm; beta-lactam; diagnosis; hypersensitivity; immediate; PENICILLIN ALLERGY; MINOR DETERMINANTS; DIAGNOSIS; HYPERSENSITIVITY; RESENSITIZATION; HISTORY;

D O I：

10.1111/all.13032

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

European Network on Drug Allergy (ENDA) has proposed an algorithm for diagnosing immediate beta-lactam (BL) allergy. We evaluated its performance in real life. During 1994-2014, 1779 patients with suspected immediate reactions to BL were evaluated following ENDA's short diagnostic algorithm. Five hundred and nine patients (28.6%) were diagnosed of BL hypersensitivity. Of them, 457 (25.7%) were at first evaluation [403 by skin tests (ST), 12 by positive IgE and 42 by controlled provocation tests (CPT)]. At second evaluation (SE), 52 additional patients (10.2% of allergic patients) were diagnosed, [50 (2.8%) by ST and 2 (0.1%) by CPT]. Time between reaction and study was significantly longer in patients diagnosed at SE (median 5 vs 42 months; IQR 34 vs 170; P < 0.0001). Anaphylaxis was significantly associated with a diagnosis at SE. European Network on Drug Allergy/EAACI protocol was appropriate and safe when evaluating BL immediate reactions. Re-evaluation should be performed, particularly when anaphylaxis and long interval to diagnosis are present.

引用

页码：1787 / 1790

页数：4

共 21 条

[1] Natural evolution of skin test sensitivity in patients allergic to β-lactam antibiotics [J].