Chiral phosphoric acid catalyzed aza-Friedel-Crafts alkylation of indoles with cyclic aryl α-ketimino esters

被引：26

作者：

Zhao, Yunlong ^{[1
,2
]}

Wang, Longsheng ^{[1
]}

Zhao, Junling ^{[2
]}

机构：

[1] Hubei Univ Technol, Inst POM Based Mat, Sch Mat & Chem Engn, Wuhan 430068, Hubei Province, Peoples R China

[2] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Organocatalysis; Aza-Friedel-Crafts alkylation; Enantioselective; Indoles; alpha-Ketimino esters; BRONSTED ACID; ENANTIOSELECTIVE ADDITION; ASYMMETRIC-SYNTHESIS; AMINO-ACIDS; N-ACYL; ALKYNYLATION; CONSTRUCTION; IMINES; KETOIMINES; BEARING;

D O I：

10.1016/j.tetlet.2016.12.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly enantioselective aza-Friedel-Crafts alkylation of indoles with cyclic aryl alpha-ketimino esters catalyzed by a chiral phosphoric acid has been developed, the corresponding alpha,alpha-disubstituted unnatural alpha-amino ester derivatives were obtained in moderate to high yields (67-85%) with high enantioselectivities (up to 93% ee) under mild reaction conditions. (C) 2016 Published by Elsevier Ltd.

引用

页码：213 / 217

页数：5

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