Dietary Nickel Chloride Induces Oxidative Intestinal Damage in Broilers

被引:40
作者
Wu, Bangyuan [1 ]
Cui, Hengmin [1 ]
Peng, Xi [1 ]
Fang, Jing [1 ]
Zuo, Zhicai [1 ]
Deng, Junliang [1 ]
Huang, Jianying [1 ]
机构
[1] Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Environm Hazards Sichuan Prov, Yaan 625014, Peoples R China
来源
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2013年 / 10卷 / 06期
关键词
broiler; intestinal mucosa; nickel chloride; oxidative damage; CARBON-MONOXIDE DEHYDROGENASE; LIPID-PEROXIDATION; DNA-DAMAGE; STRESS; DEFICIENCY; METABOLISM; TOXICITY; RAT; ANTIOXIDANTS; LIVER;
D O I
10.3390/ijerph10062109
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The purpose of this study was to investigate the oxidative damage induced by dietary nickel chloride (NiCl2) in the intestinal mucosa of different parts of the intestine of broilers, including duodenum, jejunum and ileum. A total of 240 one-day-old broilers were divided into four groups and fed on a corn-soybean basal diet as control diet or the same basal diet supplemented with 300, 600 or 900 mg/kg NiCl2 during a 42-day experimental period. The results showed that the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and the ability to inhibit hydroxy radical and glutathione (GSH) content were significantly (p < 0.05 or p < 0.01) decreased in the 300, 600 and 900 mg/kg groups in comparison with those of the control group. In contrast, malondialdehyde (MDA) content was significantly (p < 0.05 or p < 0.01) higher in the 300, 600 and 900 mg/kg groups than that in the control group. It was concluded that dietary NiCl2 in excess of 300 mg/kg could cause oxidative damage in the intestinal mucosa in broilers, which finally impaired the intestinal functions including absorptive function and mucosal immune function. The oxidative damage might be a main mechanism on the effects of NiCl2 on the intestinal health of broilers.
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页码:2109 / 2119
页数:11
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