Population-based study of breast cancer in older women: prognostic factors of relative survival and predictors of treatment

被引:16
作者
Dialla, Pegdwende Olivia [1 ,2 ]
Dabakuyo, Tienhan Sandrine [1 ,2 ]
Marilier, Sophie [3 ]
Gentil, Julie [1 ,2 ]
Roignot, Patrick [4 ]
Darut-Jouve, Ariane [5 ]
Poillot, Marie-Laure [1 ,2 ]
Quipourt, Valerie [3 ]
Arveux, Patrick [1 ,2 ]
机构
[1] Ctr Georges Francois Leclerc, Breast & Gynaecol Canc Registry Cote dOr, F-21079 Dijon, France
[2] Univ Burgundy, Fac Med, EA 4184, F-21000 Dijon, France
[3] Hop Champmaillot, Hop Jour Geriatr, Unite Pilote Coordinat Oncogeriatr Cote dOr, F-21079 Dijon, France
[4] Ctr Pathol, F-21000 Dijon, France
[5] Clin Clement Drevon, F-21000 Dijon, France
关键词
Breast cancer; Elderly women; Predictors of treatment; Prognostic factors; Relative survival; FRANCE; AGE; MORTALITY;
D O I
10.1186/1471-2407-12-472
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: A large proportion of women with breast cancer (BC) are elderly. However, there is a lack of information regarding BC prognostic factors and care in this population. The aims of this study were to assess the prognostic factors of relative survival (RS) among women with BC aged >= 75 years old and to identify the predictive factors of treatments administered to this population. Methods: A population-based study was performed using data from the Cote d'Or breast and gynaecological cancer registry. Women aged 75 years and older with primary invasive BC and resident in Cote d'Or at the time of diagnosis made between January 1998 and December 2008 were retrospectively selected. Prognostic factors of RS were estimated in a generalized linear model with a Poisson error structure. RS rate for the whole population was given at 5 years. Logistic regression models were used to identify the predictors of the treatments administered. Results: Six hundred and eighty-one women were included. Median age at diagnosis was 80. Comorbidities (p=0.02), pT stage (p=0.04), metastases (p=<0.001), having a family doctor (p=0.03) and hormone-receptor status (p=0.006) were independent prognostic factors of RS. The RS rate at 5 years for the whole population was 78.2%, 95%CI = [72.2-83.0]. Age, pT stage, metastases, histoprognostic SBR grade, hormone receptor status and comorbidities were frequently found to be predictors of treatment with surgery alone, hormone therapy alone, breast conserving surgery plus adjuvant therapy and mastectomy plus adjuvant therapy. Conclusions: Comorbid conditions adversely affect survival in older women with breast cancer. Moreover the results of this study showed that there are numerous predictors of the type of treatment administered, and that the most important were age and comorbidities.
引用
收藏
页数:10
相关论文
共 28 条
[1]  
Abe O, 2005, LANCET, V366, P2087, DOI 10.1016/s0140-6736(05)66544-0
[2]  
Andrieu JM, 1997, CANC EVALUATION TRAI
[3]  
[Anonymous], 2011, SITUATION CANC FRANC
[4]  
[Anonymous], 1997, International Union against Cancer (UICC). TNM Classification of Malignant Tumours
[5]   Lack of Survival Gain for Elderly Women with Breast Cancer [J].
Bastiaannet, Esther ;
Portielje, Johanneke E. A. ;
van de Velde, Cornelis J. H. ;
de Craen, Anton J. M. ;
van der Velde, Susanne ;
Kuppen, Peter J. K. ;
van der Geest, Lydia G. M. ;
Janssen-Heijnen, Maryska L. G. ;
Dekkers, Olaf M. ;
Westendorp, Rudi G. J. ;
Liefers, Gerrit-Jan .
ONCOLOGIST, 2011, 16 (04) :415-423
[6]   Cancer incidence and mortality in France over the period 1980-2005 [J].
Belot, A. ;
Grosclaude, P. ;
Bossard, N. ;
Jougla, E. ;
Benhamou, E. ;
Delafosse, P. ;
Guizard, A. -V. ;
Molinie, F. ;
Danzon, A. ;
Bara, S. ;
Bouvier, A. -M. ;
Tretarre, B. ;
Binder-Foucard, F. ;
Colonna, M. ;
Daubisse, L. ;
Hedelin, G. ;
Launoy, G. ;
Le Stang, N. ;
Maynadie, M. ;
Monnereau, A. ;
Troussard, X. ;
Faivre, J. ;
Collignon, A. ;
Janoray, I. ;
Arveux, P. ;
Buemi, A. ;
Raverdy, N. ;
Schvartz, C. ;
Bovet, M. ;
Cherie-Challine, L. ;
Esteve, J. ;
Remontet, L. ;
Velten, M. .
REVUE D EPIDEMIOLOGIE ET DE SANTE PUBLIQUE, 2008, 56 (03) :159-175
[7]   Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study [J].
Berrino, Franco ;
De Angelis, Roberta ;
Sant, Milena ;
Rosso, Stefano ;
Lasota, Magdalena B. ;
Coebergh, Jan W. ;
Santaquilani, Mariano .
LANCET ONCOLOGY, 2007, 8 (09) :773-783
[8]   Undertreatment strongly decreases prognosis of breast cancer in elderly women [J].
Bouchardy, C ;
Rapiti, E ;
Fioretta, G ;
Laissue, P ;
Neyroud-Caspar, I ;
Schäfer, P ;
Kurtz, J ;
Sappino, AP ;
Vlastos, G .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (19) :3580-3587
[9]   Older female cancer patients: Importance, causes, and consequences of undertreatment [J].
Bouchardy, Christine ;
Rapiti, Elisabetta ;
Blagojevic, Stina ;
Vlastos, Anne-Therese ;
Vlastos, Georges .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (14) :1858-1869
[10]   Cancer incidence and mortality in Europe, 2004 [J].
Boyle, P ;
Ferlay, J .
ANNALS OF ONCOLOGY, 2005, 16 (03) :481-488