Nanomaterial synthesis, an enabler of amyloidosis inhibition against human diseases

被引：21

作者：

Andrikopoulos, Nicholas ^{[1
]}

Li, Yuhuan ^{[1
,2
]}

Cecchetto, Luca ^{[1
,3
]}

Nandakumar, Aparna ^{[1
]}

Da Ros, Tatiana ^{[3
]}

Davis, Thomas P. ^{[1
,4
]}

Velonia, Kelly ^{[5
]}

Ke, Pu Chun ^{[1
,2
]}

机构：

[1] Monash Univ, Monash Inst Pharmaceut Sci, ARC Ctr Excellence Convergent Bionano Sci & Techn, 381 Royal Parade, Parkville, Vic 3052, Australia

[2] Fudan Univ, Zhongshan Hosp, 111 Yixueyuan Rd, Shanghai, Peoples R China

[3] Univ Trieste, Dept Chem & Pharmaceut Sci, Via Licio Giorgieri 1, I-34127 Trieste, Italy

[4] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia

[5] Univ Crete, Dept Mat Sci & Technol, Iraklion 70013, Greece

来源：

NANOSCALE | 2020年 / 12卷 / 27期

基金：

澳大利亚研究理事会;

关键词：

ALPHA-SYNUCLEIN FIBRILLATION; BETA PROTEIN FIBRILLATION; IRON-OXIDE NANOPARTICLES; AMINO-ACID-RESIDUES; IN-VITRO; POLYMER NANOPARTICLES; AGGREGATION KINETICS; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; MOLECULAR-BASIS;

D O I：

10.1039/d0nr04273k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amyloid diseases are global epidemics with no cure currently available. In the past decade, the use of engineered nanomaterials as inhibitors or probes against the pathogenic aggregation of amyloid peptides and proteins has emerged as a new frontier in nanomedicine. In this Minireview, we summarize for the first time the pivotal role of chemical synthesis in enabling the development of this multidisciplinary field.

引用

收藏

页码：14422 / 14440

页数：19

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