Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense and danger

被引:25
作者
Kim, SangSeong [1 ]
Hwang, Sun Wook [2 ,3 ]
机构
[1] Hanyang Univ, Coll Pharm, Inst Pharmaceut Sci & Technol, Ansan Shi 426791, Gyeonggi Do, South Korea
[2] Korea Univ, Coll Med, Dept Biomed Sci, Seoul 136705, South Korea
[3] Korea Univ, Ansan Hosp, Ansan Shi 425707, Gyeonggi Do, South Korea
基金
新加坡国家研究基金会;
关键词
TRPA1; Ion channel; Pain; Oxidative stress; Inflammation; Respiratory hypersensitivity; GENE-RELATED PEPTIDE; NEUROGENIC INFLAMMATION; AIRWAY INFLAMMATION; VANILLOID RECEPTOR; SENSORY NERVES; ACTIVATION; CHANNELS; EXPRESSION; TRPV1; PAIN;
D O I
10.1007/s12272-013-0098-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Transient receptor potential ankyrin subtype 1 (TRPA1) is a well-known ion channel that play a central role for pain sensation. In the peripheral sensory nerve terminals innervating the body tegument or organs, TRPA1 detects and is activated by diverse harmful environmental and internal stimuli. The TRPA1 activation results in neuronal firing, which finally sends a warning signal to our brain. However, sensitization or sustained activation of TRPA1 often causes plastic changes both in the neural pathway and in the peripheral tissues, leading to a pathologic state in tissue health and pain mediation. Recently, a unique covalent detection mode for reactive biological attacks was uncovered in the sensory mechanisms of TRPA1. Notably, the pool of the newly found reactive stimulators for TRPA1 includes oxidative stress. Here, we overview the nature of this interaction, and try to find biological meanings of the participation of such a rapid ionotrophic component in disease exacerbations. Acutely, its relatively rapid response can be understood in terms of efficiency for avoiding harmful milieu as quickly as possible, as implicated in the raison d'etre of the pain mechanism. Nonetheless, complex situations in a chronic disease progress may occur. As well, multiple interplays with known molecules on the redox defense mechanism are anticipated. At a therapeutic angle, how to control TRPA1 for promoting body's defensive potential will be a practical question but remains to be answered. Future investigations will likely give more detailed insights to understand the roles and target validity of TRPA1.
引用
收藏
页码:783 / 791
页数:9
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