miR-208a-3p suppresses cell apoptosis by targeting PDCD4 in gastric cancer

被引：36

作者：

Yin, Kai ^{[1
,2
,3
]}

Liu, Minghui ^{[2
]}

Zhang, Mei ^{[4
]}

Wang, Feng ^{[1
]}

Fen, Min ^{[1
]}

Liu, Zhijian ^{[5
]}

Yuan, Yutao ^{[5
]}

Gao, Shanting ^{[5
]}

Yang, Liuqing ^{[5
]}

Zhang, Weijie ^{[1
]}

Zhang, Jianguo ^{[6
]}

Guo, Baoliang ^{[6
]}

Xu, Jianwei ^{[3
]}

Liang, Hongwei ^{[2
]}

Chen, Xi ^{[2
]}

Guan, Wenxian ^{[1
]}

机构：

[1] Nanjing Med Univ, Clin Coll, Nanjing Drum Tower Hosp, Dept Gastrointestinal Surg, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Univ, Sch Life Sci, Jiangsu Engn Res Ctr MicroRNA Biol & Biotechnol, State Key Lab Pharmaceut Biotechnol,NJU Adv Inst, Nanjing 210046, Jiangsu, Peoples R China

[3] Bengbu Med Sch, Taixing Hosp, Dept Gen Surg, Taixing 225400, Jiangsu, Peoples R China

[4] Bengbu Med Sch, Taixing Hosp, Dept Anesthesiol, Taixing 225400, Jiangsu, Peoples R China

[5] Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Dept Gastrointestinal Surg, Nanjing 210008, Jiangsu, Peoples R China

[6] Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, Harbin 150081, Heilongjiang, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 41期

基金：

中国国家自然科学基金;

关键词：

gastric cancer; microRNA; miR; 208a-3p; PDCD4; apoptosis; DEATH; 4; PDCD4; DOWN-REGULATION; EXPRESSION; ESOPHAGEAL; GROWTH; PROLIFERATION; MICRORNA-21; BIOGENESIS; MANAGEMENT; CARCINOMA;

D O I：

10.18632/oncotarget.12006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Programmed cell death 4 (PDCD4) is a novel tumor suppressor gene and a promising target for anticancer therapies. PDCD4 is frequently downregulated in various human cancers; however, the molecular mechanism accounting for the loss expression of PDCD4 in cancers is not fully understood. In this study, we identified specific targeting sites for miR-208a-3p in the 3'-untranslated region (3'-UTR) of the PDCD4 gene which regulated PDCD4 expression. We demonstrated that miR-208a-3p suppressed apoptosis in gastric cancer cells by targeting PDCD4. We also showed that miR-208a-3p promoted the development of tumor growth in xenograft mice by negatively regulating PDCD4. Taken together, this study revealed a critical role for miR-208a-3p as an oncogenic miRNA in gastric carcinogenesis and it may provide a potential novel target for gastric cancer diagnosis and therapy.

引用

页码：67321 / 67332

页数：12

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