When Innate Immunity Meets Angiogenesis-The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension

被引：25
作者：
Bhagwani, Aneel [1 ,2 ]
Thompson, A. A. Roger [3 ]
Farkas, Laszlo [1 ]
机构：
[1] Ohio State Univ, Davis Heart & Lung Res Inst, Dept Internal Med, Div Pulm Crit Care & Sleep Med, Columbus, OH 43210 USA
[2] Virginia Commonwealth Univ, Dept Physiol & Biophys, Richmond, VA USA
[3] Univ Sheffield, Fac Med Dent & Hlth, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England
来源：
FRONTIERS IN MEDICINE | 2020年 / 7卷
关键词：
toll-like receptors; endothelial cells; angiogenesis; pulmonary hypertension; immunology; NF-KAPPA-B; PATTERN-RECOGNITION RECEPTORS; DOMAIN-CONTAINING ADAPTER; COLONY-FORMING CELLS; DOUBLE-STRANDED-RNA; MESENCHYMAL TRANSITION; CUTTING EDGE; INFLAMMATORY RESPONSE; RHEUMATOID-ARTHRITIS; PATHOGEN RECOGNITION;
D O I：
10.3389/fmed.2020.00352
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Toll-like receptors serve a central role in innate immunity, but they can also modulate cell function in various non-immune cell types including endothelial cells. Endothelial cells are necessary for the organized function of the vascular system, and part of their fundamental role is also the regulation of immune function and inflammation. In this review, we summarize the current knowledge of how Toll-like receptors contribute to the immune and non-immune functions of the endothelial cells.
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页数：12
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