Rhodium-Catalyzed Asymmetric Arylative Ring-Opening Reactions of Heterobicyclic Alkenes with Anilines

被引：31

作者：

Chen, Jingchao ^{[1
]}

Zou, Lingling ^{[1
]}

Zeng, Chaoyuan ^{[1
]}

Zhou, Yongyun ^{[1
]}

Fan, Baomin ^{[1
,2
]}

机构：

[1] Yunnan Minzu Univ, YMU HKBU Joint Lab Tradit Nat Med, Kunming 650500, Yunnan, Peoples R China

[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Kunming 650500, Yunnan, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 05期

基金：

中国国家自然科学基金;

关键词：

CRAFTS ALKYLATION REACTION; OXABICYCLIC ALKENES; ACIDS; AZABENZONORBORNADIENES; OXABENZONORBORNADIENES; STEREOCENTERS; CONSTRUCTION; DERIVATIVES; ALCOHOLS; FEATURES;

D O I：

10.1021/acs.orglett.7b03941

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric arylative ring-opening reactions of heterobicyclic alkenes with anilines have been reported for the first time. A wide range of heterobicyclic alkenes, including azabenzonorbornadienes and oxabenzonorbornadienes, were well tolerated in the reaction with various anilines, and they generally delivered the corresponding chiral aryltetralin derivatives in good to excellent enantioselectivities. The reaction is speculated to proceed through the Friedel Crafts reaction pathway.

引用

页码：1283 / 1286

页数：4

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