Oxidative stress biomarkers of exposure in the blood of cichlid species from a metal-contaminated river

被引：157

作者：

Gaspar Ruas, Clarissa Bonafe ^{[1
]}

Carvalho, Cleoni dos Santos ^{[1
]}

Selistre de Araujo, Heloisa Sobreiro ^{[1
]}

Gaeta Espindola, Evaldo Luiz ^{[2
]}

Fernandes, Marisa Narciso ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Dept Ciencias Fisiol, BR-13565905 Sao Carlos, SP, Brazil

[2] Univ Sao Paulo, Escola Engn Sao Carlos, Dept Hidraul & Saneamento, BR-13566590 Sao Carlos, SP, Brazil

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2008年 / 71卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

blood; erythrocytes; fish; cichlids; oxidative stress; antioxidant enzymes; metals; pollution;

D O I：

10.1016/j.ecoenv.2007.08.018

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The oxidative stress biomarkers of exposure, such as reduced glutathione (GSH), activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the levels of lipid peroxidation (LPO), were measured in the blood of three cichlid fish (Oreochromis niloticus, Tilapia rendalli, and Geophagus brasiliensis) taken during two seasons from two sites, unpolluted and polluted by industrial effluents, to evaluate the effectiveness of these biomarkers in assessing the impact of water contamination. The LPO levels in the blood were higher in fish from the metal-contaminated site and the chronic exposure led to significant changes in GPx, CAT, and SOD activities in all three cichlid species. The considerable variation of responses in these cichlids to water contamination evidenced differences in sensitivity to the metal contamination and/or in the potential to respond to it highlighting the importance of using a set of related biomarkers to assess the impact of water contamination. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：86 / 93

页数：8

共 59 条

[31] Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms [J].

Livingstone, DR .

MARINE POLLUTION BULLETIN, 2001, 42 (08) :656-666

[32]

Mackereth F.J.H., 1978, WATER ANAL SOME REVI, V36

[33] Antioxidant processes of the wild tambaqui, Colossoma macropomum (Osteichthyes, Serrasalmidae) from the Amazon [J].

Marcon, JL ;

Wilhelm, D .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 1999, 123 (03) :257-263

[34] Gill cellular changes induced by copper exposure in the south American tropical freshwater fish Prochilodus scrofa [J].

Mazon, AF ;

Cerqueira, CCC ;

Fernandes, MN .

ENVIRONMENTAL RESEARCH, 2002, 88 (01) :52-63

[35]

MILLS GC, 1959, J BIOL CHEM, V234, P502

[36] Partial oxidative-stress perturbs membrane permeability and fluidity of fish nucleated red blood cells [J].

Nagasaka, R ;

Okamoto, N ;

Ushio, H .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2004, 139 (04) :259-266

[37] Reactive oxygen species, antioxidants, and the mammalian thioredoxin system [J].

Nordberg, J ;

Arnér, ESJ .

FREE RADICAL BIOLOGY AND MEDICINE, 2001, 31 (11) :1287-1312

[38] Biomarkers of oxidative stress:: a comparative study of river Yamuna fish Wallago attu (Bl. & Schn.) [J].

Pandey, S ;

Parvez, S ;

Sayeed, I ;

Haque, R ;

Bin-Hafeez, B ;

Raisuddin, S .

SCIENCE OF THE TOTAL ENVIRONMENT, 2003, 309 (1-3) :105-115

[39] EFFECTS OF CU, ZN AND CR SALTS ON ANTIOXIDANT ENZYME-ACTIVITIES IN-VITRO OF RED-BLOOD-CELLS OF A MARINE FISH DICENTRARCHUS-LABRAX [J].

ROCHE, H ;

BOGE, G .

TOXICOLOGY IN VITRO, 1993, 7 (05) :623-629

[40] Fish blood parameters as a potential tool for identification of stress caused by environmental factors and chemical intoxication [J].

Roche, H ;

Boge, G .

MARINE ENVIRONMENTAL RESEARCH, 1996, 41 (01) :27-43

← 1 2 3 4 5 6 →