共 21 条
Determinants of plasma calretinin in patients with malignant pleural mesothelioma
被引:2
作者:
Lehnert, Martin
[1
]
Weber, Daniel G.
[1
]
Taeger, Dirk
[1
]
Raiko, Irina
[1
]
Kollmeier, Jens
[2
]
Stephan-Falkenau, Susann
[3
]
Bruening, Thomas
[1
]
Johnen, Georg
[1
]
机构:
[1] Inst Ruhr Univ Bochum IPA, Inst Prevent & Occupat Med, German Social Accid In Insurance, Burkle de la Camp Pl 1, D-44789 Bochum, Germany
[2] Helios Clin Emil Behring, Clin Pneumol, Walterhoferstr 11, D-14165 Berlin, Germany
[3] Helios Clin Emil Von Behring, Inst Pathol, Walterhoferstr 11, D-14165 Berlin, Germany
关键词:
Malignant pleural mesothelioma;
Molecular marker;
Plasma calretinin;
Enzyme-linked immunosorbent assay;
Tissue staining;
BIOMARKERS;
EXPRESSION;
DIAGNOSIS;
MARKER;
D O I:
10.1186/s13104-020-05187-y
中图分类号:
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
ObjectiveCalretinin is a well-known immunohistochemical tissue marker in the diagnosis of malignant mesothelioma. Promising results also indicate the use in early detection. In the present cross-sectional survey, correlations of calretinin plasma levels with clinical features were investigated.Plasma samples of 60 patients with malignant pleural mesothelioma (MPM) and 111 cancer-free controls formerly exposed to asbestos were compared. Calretinin concentrations were determined in plasma using an enzyme-linked immunosorbent assay (ELISA).ResultsThe median concentration was higher in MPM patients than in controls (0.79 vs. 0.23 ng/ml; p<0.0001). Patients with epithelioid MPM or biphasic MPM had higher calretinin plasma levels than patients with sarcomatoid MPM. Strong expression of calretinin in the tumor tissue was associated with higher plasma levels. Preoperative patients showed higher levels of calretinin than patients after thoracic surgery (1.20 vs. 0.67 ng/ml; p=0.096). The suitability of plasma calretinin has been confirmed as a tumor marker in the differential diagnosis of epithelioid MPM. The value of plasma calretinin for therapy monitoring or as a prognostic marker should be further investigated.
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