Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp RK10-F058

被引：12
|
作者：
Nogawa, Toshihiko [1 ]
Kato, Naoki [2 ]
Shimizu, Takeshi [1 ]
Okano, Akiko [1 ]
Futamura, Yushi [1 ]
Takahashi, Shunji [2 ]
Osada, Hiroyuki [1 ]
机构：
[1] RIKEN Ctr Sustainable Resource Sci, Chem Biol Res Grp, 2-1 Hirosawa, Wako, Saitama 3510198, Japan
[2] RIKEN Ctr Sustainable Resource Sci, Nat Product Biosynthesis Res Unit, Saitama, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 01期
关键词：
MICROBIAL METABOLITES; NATURAL-PRODUCTS; AMINO-ACIDS; EQUISETIN; DERIVATIVES; INHIBITOR; LIBRARY;
D O I：
10.1038/ja.2017.103
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Two new decaline metabolites, wakodecalines A and B, were isolated from a fungus, Pyrenochaetopsis sp. RK10-F058, by screening for structurally unique metabolites using LC/MS analysis. Their structures were determined on the basis of NMR and mass spectrometric measurements. The absolute structures were confirmed by a combination of chemical methods including chemical degradation, a modified Mosher's method and Marfey's method, and comparison of the experimental electronic CD (ECD) spectrum with calculated one. Both compounds had a cyclopentanone-fused decaline skeleton and an N-methylated amino acid moiety derived from a serine. They showed moderate antimalarial activity against the Plasmodium falciparum 3D7 strain.
引用
收藏
页码：123 / 128
页数：6
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