Polycystic ovaries and obesity

被引：63
作者：
Messinis, Ioannis E. [1 ]
Messini, Christina I. [1 ]
Anifandis, George [2 ]
Dafopoulos, Konstantinos [1 ]
机构：
[1] Univ Thessaly, Sch Hlth Sci, Fac Med, Dept Obstet & Gynaecol,Obstet & Gynaecol, Larisa 41110, Greece
[2] Univ Thessaly, Sch Hlth Sci, Fac Med, Dept Obstet & Gynaecol,Embryol, Larisa 41110, Greece
来源：
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2015年 / 29卷 / 04期
关键词：
polycystic ovaries; obesity; infertility; ovulation induction; reproduction; FOLLICLE-STIMULATING-HORMONE; CLOMIPHENE CITRATE INDUCTION; AND/OR PHYSICAL-EXERCISE; LIFE-STYLE MODIFICATION; BODY-MASS INDEX; INSULIN-RESISTANCE; OVULATION INDUCTION; LUTEINIZING-HORMONE; WEIGHT-LOSS; ANOVULATORY INFERTILITY;
D O I：
10.1016/j.bpobgyn.2014.11.001
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Almost 50% of the women with polycystic ovary syndrome (PCOS) are obese. Obesity in PCOS affects reproduction via various mechanisms. Hyperandrogenism, increased luteinizing hormone (LH) and insulin resistance play a pivotal role. Several substances produced by the adipose tissue including leptin, adiponectin, resistin and visfatin may play a role in the pathophysiology of PCOS. Infertility in PCOS is related to anovulation. For induction of ovulation, clomiphene citrate and human gonadotrophins are first- and second-line treatments, respectively. Other treatment modalities include the use of insulin sensitizers, such as metformin as well as aromatase inhibitors and laparoscopic ovarian drilling, while in vitro fertilization is the last resort. Obesity can adversely affect infertility treatment in PCOS. Diet and lifestyle changes are recommended for the obese women before they attempt conception. The use of anti-obesity drugs and bariatric surgery in PCOS require further evaluation. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：479 / 488
页数：10
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