Neuro-Immune Interactions in Severe COVID-19 Infection

被引：3

作者：

Rossi, Elena ^{[1
]}

Mutti, Luciano ^{[2
,3
,4
]}

Morrione, Andrea ^{[2
]}

Giordano, Antonio ^{[1
,2
]}

机构：

[1] Univ Siena, Dept Med Surg & Neurosci, I-53100 Siena, Italy

[2] Temple Univ, Sbarro Inst Canc Res & Mol Med, Ctr Biotechnol, Dept Biol,Coll Sci & Technol, Philadelphia, PA 19122 USA

[3] Italian Grp Res & Therapy Mesothelioma GIMe, I-27058 Voghera, Italy

[4] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Via Vetoio,Coppito 2, I-67100 Laquila, Italy

来源：

PATHOGENS | 2022年 / 11卷 / 11期

关键词：

severe COVID-19; neurologic symptoms; renin-angiotensin system; inflammatory responses; lymphopenia; neuro-immune interactions; aging; ANGIOTENSIN-CONVERTING ENZYME; BRAIN; SARS-COV-2; CORONAVIRUS; DISEASE; NEUROINFLAMMATION; IDENTIFICATION; BARRIER; INNATE; SYSTEM;

D O I：

10.3390/pathogens11111256

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

SARS-CoV-2 is a new coronavirus that has affected the world since 2019. Interstitial pneumonia is the most common clinical presentation, but additional symptoms have been reported, including neurological manifestations. Severe forms of infection, especially in elderly patients, present as an excessive inflammatory response called "cytokine storm", which can lead to acute respiratory distress syndrome (ARDS), multiorgan failure and death. Little is known about the relationship between symptoms and clinical outcomes or the characteristics of virus-host interactions. The aim of this narrative review is to highlight possible links between neurological involvement and respiratory damage mediated by pathological inflammatory pathways in SARS-CoV-2 infection. We will focus on neuro-immune interactions and age-related immunity decline and discuss some pathological mechanisms that contribute to negative outcomes in COVID-19 patients. Furthermore, we will describe available therapeutic strategies and their effects on COVID-19 neurological symptoms.

引用

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