The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm

被引：16

作者：

Bonnefond, Amelie ^{[1
,5
]}

Karamitri, Angeliki ^{[2
,3
,4
]}

Jockers, Ralf ^{[2
,3
,4
]}

Froguel, Philippe ^{[1
,5
]}

机构：

[1] Univ Lille, Inst Pasteur Lille, European Genom Inst Diabet EGID, CNRS,UMR 8199, F-59000 Lille, France

[2] INSERM, Inst Cochin, U1016, F-75014 Paris, France

[3] CNRS, UMR 8104, F-75014 Paris, France

[4] Univ Paris 05, Sorbonne Paris Cite, F-75006 Paris, France

[5] Hammersmith Hosp, Imperial Coll London, Sch Publ Hlth, Dept Genom Common Dis, London W12 0NN, England

来源：

CELL METABOLISM | 2016年 / 24卷 / 03期

关键词：

TYPE-2; MTNR1B; RISK; SECRETION; VARIANTS;

D O I：

10.1016/j.cmet.2016.08.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：345 / 347

页数：3

共 12 条

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Hakaste, Liisa ;

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Groop, Leif ;

Mulder, Hindrik .

CELL METABOLISM, 2016, 23 (06) :1067-1077

[12] Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors [J].

van de Bunt, Martijn ;

Fox, Jocelyn E. Manning ;

Dai, Xiaoqing ;

Barrett, Amy ;

Grey, Caleb ;

Li, Lei ;

Bennett, Amanda J. ;

Johnson, Paul R. ;

Rajotte, Raymond V. ;

Gaulton, Kyle J. ;

Dermitzakis, Emmanouil T. ;

MacDonald, Patrick E. ;

McCarthy, Mark I. ;

Gloyn, Anna L. .

PLOS GENETICS, 2015, 11 (12)

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