Chemical approaches to deciphering the glycosaminoglycan code

被引：117

作者：

Gama, CI ^{[1
]}

Hsieh-Wilson, LC ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Howard Hughes Med Inst, Pasadena, CA 91125 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2005年 / 9卷 / 06期

关键词：

D O I：

10.1016/j.cbpa.2005.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosaminoglycans are sulfated biopolymers with rich chemical diversity and complex functions in vivo, contributing to processes ranging from cell growth and neuronal development to viral invasion and neurodegenerative disease. Recent studies suggest that glycosaminoglycans may encode information in the form of a 'sulfation code,' whereby discrete modifications to the polysaccharide backbone may direct the location or activities of proteins.

引用

页码：609 / 619

页数：11

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