Massive CD8 T Cell Response to Primary HIV Infection in the Setting of Severe Clinical Presentation

被引：3

作者：

Arnoczy, Gretchen S. ^{[1
]}

Ferrari, Guido ^{[2
]}

Goonetilleke, Nilu ^{[3
]}

Corrah, Tumena ^{[3
]}

Li, Hui ^{[4
]}

Kuruc, Joann ^{[1
]}

Schmitz, John L. ^{[5
]}

McGee, Kara ^{[6
]}

Hicks, Charles ^{[6
]}

Eron, Joseph J. ^{[1
]}

机构：

[1] Univ N Carolina, Div Infect Dis, Chapel Hill, NC USA

[2] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

[3] Univ Oxford, WIMM, Oxford, England

[4] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[5] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA

[6] Duke Univ, Med Ctr, Dept Infect Dis, Durham, NC USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2012年 / 28卷 / 08期

关键词：

PRIMARY IMMUNE-RESPONSE; DIRECT VISUALIZATION;

D O I：

10.1089/aid.2011.0145

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute HIV-1 infection causes a rapid total body depletion of CD4(+) T cells in most individuals and HIV-1-specific CD8(+) T cell expansion in response to viral replication. A numerically high CD8 T cell response may indicate limited T cell repertoire against HIV and rapid progression. We present a detailed evaluation of an acutely infected individual with a strong HIV-1-specific CD8 T cell response targeting multiple epitopes demonstrating that the upper limit of CD8 expansion in this setting may be much higher than previously reported and was likely driven by the narrow HIV-specific response.

引用

页码：789 / 792

页数：4

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