Fight against novel coronavirus: A perspective of medicinal chemists

被引：54

作者：

Amin, Sk Abdul ^{[1
]}

Jha, Tarun ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Pharmaceut Technol, Div Med & Pharmaceut Chem, Nat Sci Lab, Kolkata 700032, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 201卷

关键词：

COVID-19; SARS-CoV-2; Anti-HCoV agent; Drug repurposing; Target based screening; Molecular modelling; SPIKE; 2019-NCOV; NITAZOXANIDE; CHLOROQUINE; EVOLUTION; COVID-19; RECEPTOR;

D O I：

10.1016/j.ejmech.2020.112559

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The ongoing novel coronavirus disease (COVID-19) pandemic makes us painfully perceive that our bullet shells are blank so far for fighting against severe human coronavirus (HCoV). In spite of vast research work, it is crystal clear that the evident does not warrant the commercial blossoming of anti-HCoV drugs. In this circumstance, drug repurposing and/or screening of databases are the only fastest option. This study is an initiative to recapitulate the medicinal chemistry of severe acute respiratory syndrome (SARS)-CoV-2 (SARS-CoV-2). The aim is to present an exquisite delineation of the current research from the perspective of a medicinal chemist to allow the rapid development of anti-SARS-CoV-2 agents. (C) 2020 Elsevier Masson SAS. All rights reserved.

引用

页数：12

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