α,α-Diarylprolinols: bifunctional organocatalysts for asymmetric synthesis

被引：144

作者：

Lattanzi, Alessandra ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Chim, I-84084 Fisciano, Italy

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 12期

关键词：

ENANTIOSELECTIVE CATALYTIC EPOXIDATION; VICINAL AMINO-ALCOHOLS; OXA-MICHAEL ADDITION; CONJUGATE ADDITION; ALPHA; BETA-UNSATURATED KETONES; ORGANIC CATALYSIS; ALDOL REACTION; EFFICIENT ORGANOCATALYSTS; MALONATE ESTERS; C-C;

D O I：

10.1039/b900098d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Readily accessible alpha,alpha-diarylprolinols have been recently exploited as useful organocatalysts in different asymmetric reactions. It has been proposed that they operate either via bifunctional activation of the reactive partners through non-covalent interactions or via formation of covalent enamine and iminium intermediates. This feature article describes the employment of alpha,alpha-diarylprolinols as catalysts in the epoxidation of alpha,beta-enones, aldol reaction, cycloaddition, and carbon-carbon and carbon-heteroatom bond forming reactions.

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页码：1452 / 1463

页数：12

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