Effectiveness of leukocyte filters in reducing tumor cell contamination after intraoperative blood salvage in lung cancer patients

被引：55
作者：
Perseghin, P
Vigano, M
Rocco, G
DellaPona, C
Buscemi, A
Rizzi, A
机构：
[1] AZIENDA OSPEDALIERA OSPED E MORELLI,DIV CHIRURG TORACICA,I-23039 SONDALO,SO,ITALY
[2] AZIENDA OSPEDALIERA OSPED E MORELLI,SERV ANAT PATOL,I-23039 SONDALO,SO,ITALY
来源：
VOX SANGUINIS | 1997年 / 72卷 / 04期
关键词：
D O I：
10.1046/j.1423-0410.1997.7240221.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: In an effort to reduce allogeneic blood transfusions in patients undergoing elective surgery for lung cancer, we investigated the effectiveness of a method of processing shed blood with an automated device for intra operative blood salvage (IOBS) and filtration with a 3rd-generation polyester filter to remove tumor cells. Methods: Sixteen patients were operated on for different types of lung cancer We searched for malignant cells in pre- and postprocessed shed blood employing density gradient centrifugation, staining of cytospins with hematoxylin-eosin, and antibodies to human cytokeratins. Results: In 9 out of 16 cases (56%), neoplastic cells were detected in prefiltration samples, but none were found in postfiltration cytospins. Conclusion: IOBS combined with appropriate filtration could be a very useful and safe tool in reducing allogeneic blood transfusion in cancer patients.
引用
收藏
页码：221 / 224
页数：4
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