Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications

被引：56
|
作者：
Basnett, P. [1 ]
Ching, K. Y. [3 ]
Stolz, M. [3 ]
Knowles, J. C. [4 ,5 ]
Boccaccini, A. R. [6 ]
Smith, C. [1 ]
Locke, I. C. [2 ]
Keshavarz, T. [1 ]
Roy, I. [1 ]
机构：
[1] Univ Westminster, Sch Life Sci, Dept Appl & Mol Biosci, London W1W 6UW, England
[2] Univ Westminster, Sch Life Sci, Dept Biomed Sci, London W1W 6UW, England
[3] Univ Southampton, NCATS, Southampton SO17 1BJ, Hants, England
[4] UCL, UCL Eastman Dent Inst, Div Biomat & Tissue Engn, London WC1X 8LD, England
[5] Dankook Univ, WCU Res Ctr Nanobiomed Sci, Cheonan Si 330714, Chungnam, South Korea
[6] Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, D-91058 Erlangen, Germany
来源：
REACTIVE & FUNCTIONAL POLYMERS | 2013年 / 73卷 / 10期
基金：
英国工程与自然科学研究理事会;
关键词：
Polyhydroxyalkanoates; Cytotoxicity; Biodegradability; Poly(3-hydroxyoctanoate); Poly(3-hydroxybutyrate); POLYHYDROXYALKANOATES; BIODEGRADABILITY; MISCIBILITY; DEGRADATION; SCAFFOLDS;
D O I：
10.1016/j.reactfunctpolym.2013.03.019
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Novel Poly(3-hydroxybutyrate)/Poly(3-hydroxyoctanoate) blends were developed with varying amounts of Poly(3-hydroxyoctanoate), P(3HO) and Poly(3-hydroxybutyrate), P(3HB) for their potential use in various medical applications. These blend films exhibited higher tensile strength and Young's modulus values compared to neat P(3HO). The overall protein adsorption and % cell viability was also found to be significantly higher in the blend films than the neat P(3HO) film. Hydrolytic degradation was faster in the blend films and the degradation rate could potentially be tailored to achieve the optimum rate required for a particular medical application. Hence, these novel blends were found to be highly biocompatible with surface, mechanical and thermal properties suitable for a range of potential medical applications, a great step forward in the area of medical materials. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1340 / 1348
页数：9
相关论文
共 50 条
  • [21] THERMAL-BEHAVIOR AND MISCIBILITY OF POLY(3-HYDROXYBUTYRATE)/POLY(VINYL ALCOHOL) BLENDS
    AZUMA, Y
    YOSHIE, N
    SAKURAI, M
    INOUE, Y
    CHUJO, R
    POLYMER, 1992, 33 (22) : 4763 - 4767
  • [22] The structure-hydrolysis relationship of poly(3-hydroxybutyrate)
    Kucera, Frantisek
    Petrus, Josef
    Jancar, Josef
    POLYMER TESTING, 2019, 80
  • [23] Modification of Poly(3-hydroxybutyrate)-co-Poly(3-hydroxyvalerate) with Natural Rubber
    Coelho, Jorge F. J.
    Gois, Joana R.
    Fonseca, Ana C.
    Gil, M. H.
    JOURNAL OF APPLIED POLYMER SCIENCE, 2010, 116 (02) : 718 - 726
  • [24] Functionalized tricalcium phosphate and poly(3-hydroxyoctanoate) derived composite scaffolds as platforms for the controlled release of diclofenac
    Skibinski, Szymon
    Cichon, Ewelina
    Harazna, Katarzyna
    Marcello, Elena
    Roy, Ipsita
    Witko, Malgorzata
    Slosarczyk, Anna
    Czechowska, Joanna
    Guzik, Maciej
    Zima, Aneta
    CERAMICS INTERNATIONAL, 2021, 47 (03) : 3876 - 3883
  • [25] Poly(3-hydroxybutyrate) and Human Microbiota (Review)
    A. P. Bonartsev
    V. V. Voinova
    G. A. Bonartseva
    Applied Biochemistry and Microbiology, 2018, 54 : 547 - 568
  • [26] Study of miscibility, crystallization, mechanical properties, and thermal stability of blends of poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-4-hydroxybutyrate)
    Luo, Rongcong
    Xu, Kaitian
    Chen, Guo-Qiang
    JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 105 (06) : 3402 - 3408
  • [27] Poly(3-hydroxybutyrate) and Human Microbiota (Review)
    Bonartsev, A. P.
    Voinova, V. V.
    Bonartseva, G. A.
    APPLIED BIOCHEMISTRY AND MICROBIOLOGY, 2018, 54 (06) : 547 - 568
  • [28] Poly(3-hydroxybutyrate) Nanocomposites with Cellulose Nanocrystals
    Usurelu, Catalina Diana
    Badila, Stefania
    Frone, Adriana Nicoleta
    Panaitescu, Denis Mihaela
    POLYMERS, 2022, 14 (10)
  • [29] Degradation of poly(3-hydroxybutyrate) by soil streptomycetes
    A. Manna
    P. Giri
    A.K. Paul
    World Journal of Microbiology and Biotechnology, 1999, 15 : 705 - 709
  • [30] Fabrication of a novel poly(3-hydroxyoctanoate)/nanoscale bioactive glass composite film with potential as a multifunctional wound dressing
    Rai, Ranjana
    Boccaccini, Aldo R.
    Knowles, Jonathan C.
    Locke, Ian C.
    Gordge, Michael P.
    Mc Cormick, Aine.
    Salih, Vehid
    Mordon, Nicola
    Keshavarz, Tajalli
    Roy, Ipsita
    5TH INTERNATIONAL CONFERENCE ON TIMES OF POLYMERS TOP AND COMPOSITES, 2010, 1255 : 126 - +
12345