[3] Univ Algarve, Dept Biomed Sci & Med, Ctr Biomed Res CBMR, Faro, Portugal
来源:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
|
2017年
/
28卷
/
04期
关键词:
LENGTH POLYGLUTAMINE EXPANSIONS;
TERM OLFACTORY HABITUATION;
GENOME-WIDE ASSOCIATION;
CHAIN AMINO-ACIDS;
STRESS GRANULES;
SACCHAROMYCES-CEREVISIAE;
CAENORHABDITIS-ELEGANS;
DROSOPHILA HOMOLOG;
PROTEIN EXPRESSION;
GENE-EXPRESSION;
D O I:
10.1016/j.tem.2016.12.006
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Ataxin-2 is a polyglutamine protein implicated in several biological processes such as RNA metabolism and cytoskeleton reorganization. Ataxin-2 is highly expressed in various tissues including the hypothalamus, a brain region that controls food intake and energy balance. Ataxin-2 expression is influenced by nutritional status. Emerging studies discussed here now show that ataxin-2 deficiency correlates with insulin resistance and dyslipidemia, an action mediated via the mTOR pathway, suggesting that ataxin-2 might play key roles in metabolic homeostasis including body weight regulation, insulin sensitivity, and cellular stress responses. In this review we also discuss the relevance of ataxin-2 in the hypothalamic regulation of energy balance, and its potential as a therapeutic target in metabolic disorders such as obesity.