Unraveling the Role of Ataxin-2 in Metabolism

被引：30

作者：

Carmo-Silva, Sara ^{[1
,2
]}

Nobrega, Clevio ^{[3
]}

de Almeida, Luis Pereira ^{[1
,2
]}

Cavadas, Claudia ^{[1
,2
]}

机构：

[1] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, Coimbra, Portugal

[2] Univ Coimbra, Fac Pharm, Coimbra, Portugal

[3] Univ Algarve, Dept Biomed Sci & Med, Ctr Biomed Res CBMR, Faro, Portugal

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2017年 / 28卷 / 04期

关键词：

LENGTH POLYGLUTAMINE EXPANSIONS; TERM OLFACTORY HABITUATION; GENOME-WIDE ASSOCIATION; CHAIN AMINO-ACIDS; STRESS GRANULES; SACCHAROMYCES-CEREVISIAE; CAENORHABDITIS-ELEGANS; DROSOPHILA HOMOLOG; PROTEIN EXPRESSION; GENE-EXPRESSION;

D O I：

10.1016/j.tem.2016.12.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ataxin-2 is a polyglutamine protein implicated in several biological processes such as RNA metabolism and cytoskeleton reorganization. Ataxin-2 is highly expressed in various tissues including the hypothalamus, a brain region that controls food intake and energy balance. Ataxin-2 expression is influenced by nutritional status. Emerging studies discussed here now show that ataxin-2 deficiency correlates with insulin resistance and dyslipidemia, an action mediated via the mTOR pathway, suggesting that ataxin-2 might play key roles in metabolic homeostasis including body weight regulation, insulin sensitivity, and cellular stress responses. In this review we also discuss the relevance of ataxin-2 in the hypothalamic regulation of energy balance, and its potential as a therapeutic target in metabolic disorders such as obesity.

引用

页码：309 / 318

页数：10

共 98 条

[1] Spinocerebellar ataxia type 2 (SCA2) in an Egyptian family presenting with polyphagia and marked CAG expansion in infancy [J].

Abdel-Aleem, Alice ;

Zaki, Maha .

JOURNAL OF NEUROLOGY, 2008, 255 (03) :413-419

[2] DAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1 [J].

Al-Ramahi, Ismael ;

Perez, Alma M. ;

Lim, Janghoo ;

Zhang, Minghang ;

Sorensen, Rie ;

de Haro, Maria ;

Branco, Joana ;

Pulst, Stefan M. ;

Zoghbi, Huda Y. ;

Botas, Juan .

PLOS GENETICS, 2007, 3 (12) :2551-2564

[3] Structural and functional analysis of ataxin-2 and ataxin-3 [J].

Albrecht, M ;

Golatta, M ;

Wüllner, U ;

Lengauer, T .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (15) :3155-3170

[4] Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective [J].

Albuquerque, David ;

Stice, Eric ;

Rodriguez-Lopez, Raquel ;

Manco, Licino ;

Nobrega, Clevio .

MOLECULAR GENETICS AND GENOMICS, 2015, 290 (04) :1191-1221

[5] Homeodomain Protein Otp and Activity-Dependent Splicing Modulate Neuronal Adaptation to Stress [J].

Amir-Zilberstein, Liat ;

Blechman, Janna ;

Sztainberg, Yehezkel ;

Norton, William N. J. ;

Reuveny, Adriana ;

Borodovsky, Nataliya ;

Tahor, Maayan ;

Bonkowsky, Joshua L. ;

Bally-Cuif, Laure ;

Chen, Alon ;

Levkowitz, Gil .

NEURON, 2012, 73 (02) :279-291

[6] RNA granules: post-transcriptional and epigenetic modulators of gene expression [J].

Anderson, Paul ;

Kedersha, Nancy .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (06) :430-436

[7] Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways [J].

Arimoto, Kyoko ;

Fukuda, Hiroyuki ;

Imajoh-Ohmi, Shinobu ;

Saito, Haruo ;

Takekawa, Mutsuhiro .

NATURE CELL BIOLOGY, 2008, 10 (11) :1324-U167

[8] 12q24 locus association with type 1 diabetes: SH2B3 or ATXN2 ? [J].

Auburger, Georg ;

Gispert, Suzana ;

Lahut, Suna ;

Oemuer, Oezguer ;

Damrath, Ewa ;

Heck, Melanie ;

Basak, Nazli .

WORLD JOURNAL OF DIABETES, 2014, 5 (03) :316-327

[9]

Auburger Georg W J, 2012, Handb Clin Neurol, V103, P423, DOI 10.1016/B978-0-444-51892-7.00026-7

[10] Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma [J].

Bailey, Jessica N. Cooke ;

Loomis, Stephanie J. ;

Kang, Jae H. ;

Allingham, R. Rand ;

Gharahkhani, Puya ;

Khor, Chiea Chuen ;

Burdon, Kathryn P. ;

Aschard, Hugues ;

Chasman, Daniel I. ;

Igo, Robert P., Jr. ;

Hysi, Pirro G. ;

Glastonbury, Craig A. ;

Ashley-Koch, Allison ;

Brilliant, Murray ;

Brown, Andrew A. ;

Budenz, Donald L. ;

Buil, Alfonso ;

Cheng, Ching-Yu ;

Choi, Hyon ;

Christen, William G. ;

Curhan, Gary ;

De Vivo, Immaculata ;

Fingert, John H. ;

Foster, Paul J. ;

Fuchs, Charles ;

Gaasterland, Douglas ;

Gaasterland, Terry ;

Hewitt, Alex W. ;

Hu, Frank ;

Hunter, David J. ;

Khawaja, Anthony P. ;

Lee, Richard K. ;

Li, Zheng ;

Lichter, Paul R. ;

Mackey, David A. ;

McGuffin, Peter ;

Mitchell, Paul ;

Moroi, Sayoko E. ;

Perera, Shamira A. ;

Pepper, Keating W. ;

Qi, Qibin ;

Realini, Tony ;

Richards, Julia E. ;

Ridker, Paul M. ;

Rimm, Eric ;

Ritch, Robert ;

Ritchie, Marylyn ;

Schuman, Joel S. ;

Scott, William K. ;

Singh, Kuldev .

NATURE GENETICS, 2016, 48 (02) :189-194

← 1 2 3 4 5 6 7 8 9 10 →