Unraveling the Role of Ataxin-2 in Metabolism

被引:28
|
作者
Carmo-Silva, Sara [1 ,2 ]
Nobrega, Clevio [3 ]
de Almeida, Luis Pereira [1 ,2 ]
Cavadas, Claudia [1 ,2 ]
机构
[1] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, Coimbra, Portugal
[2] Univ Coimbra, Fac Pharm, Coimbra, Portugal
[3] Univ Algarve, Dept Biomed Sci & Med, Ctr Biomed Res CBMR, Faro, Portugal
来源
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2017年 / 28卷 / 04期
关键词
LENGTH POLYGLUTAMINE EXPANSIONS; TERM OLFACTORY HABITUATION; GENOME-WIDE ASSOCIATION; CHAIN AMINO-ACIDS; STRESS GRANULES; SACCHAROMYCES-CEREVISIAE; CAENORHABDITIS-ELEGANS; DROSOPHILA HOMOLOG; PROTEIN EXPRESSION; GENE-EXPRESSION;
D O I
10.1016/j.tem.2016.12.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Ataxin-2 is a polyglutamine protein implicated in several biological processes such as RNA metabolism and cytoskeleton reorganization. Ataxin-2 is highly expressed in various tissues including the hypothalamus, a brain region that controls food intake and energy balance. Ataxin-2 expression is influenced by nutritional status. Emerging studies discussed here now show that ataxin-2 deficiency correlates with insulin resistance and dyslipidemia, an action mediated via the mTOR pathway, suggesting that ataxin-2 might play key roles in metabolic homeostasis including body weight regulation, insulin sensitivity, and cellular stress responses. In this review we also discuss the relevance of ataxin-2 in the hypothalamic regulation of energy balance, and its potential as a therapeutic target in metabolic disorders such as obesity.
引用
收藏
页码:309 / 318
页数:10
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