Unraveling the Role of Ataxin-2 in Metabolism

被引:28
|
作者
Carmo-Silva, Sara [1 ,2 ]
Nobrega, Clevio [3 ]
de Almeida, Luis Pereira [1 ,2 ]
Cavadas, Claudia [1 ,2 ]
机构
[1] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, Coimbra, Portugal
[2] Univ Coimbra, Fac Pharm, Coimbra, Portugal
[3] Univ Algarve, Dept Biomed Sci & Med, Ctr Biomed Res CBMR, Faro, Portugal
来源
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2017年 / 28卷 / 04期
关键词
LENGTH POLYGLUTAMINE EXPANSIONS; TERM OLFACTORY HABITUATION; GENOME-WIDE ASSOCIATION; CHAIN AMINO-ACIDS; STRESS GRANULES; SACCHAROMYCES-CEREVISIAE; CAENORHABDITIS-ELEGANS; DROSOPHILA HOMOLOG; PROTEIN EXPRESSION; GENE-EXPRESSION;
D O I
10.1016/j.tem.2016.12.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Ataxin-2 is a polyglutamine protein implicated in several biological processes such as RNA metabolism and cytoskeleton reorganization. Ataxin-2 is highly expressed in various tissues including the hypothalamus, a brain region that controls food intake and energy balance. Ataxin-2 expression is influenced by nutritional status. Emerging studies discussed here now show that ataxin-2 deficiency correlates with insulin resistance and dyslipidemia, an action mediated via the mTOR pathway, suggesting that ataxin-2 might play key roles in metabolic homeostasis including body weight regulation, insulin sensitivity, and cellular stress responses. In this review we also discuss the relevance of ataxin-2 in the hypothalamic regulation of energy balance, and its potential as a therapeutic target in metabolic disorders such as obesity.
引用
收藏
页码:309 / 318
页数:10
相关论文
共 50 条
  • [1] Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes
    Carmo-Silva, Sara
    Ferreira-Marques, Marisa
    Nobrega, Clevio
    Botelho, Mariana
    Costa, Daniela
    Aveleira, Celia A.
    Pulst, Stefan M.
    de Almeida, Luis Pereira
    Cavadas, Claudia
    JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2023, 70 (01)
  • [2] Epigenetics and ataxin-2 locus
    Laffita-Mesa, J. M.
    Bauer, P.
    Kouri, V.
    Pena Serrano, L.
    Roskams, J.
    Almaguer-Gotay, D.
    Aguiar Santiago, J.
    Gonzalez-Zaldivar, Y.
    Velazquez-Perez, L. C.
    Montes Brown, J.
    MOVEMENT DISORDERS, 2012, 27 : S487 - S487
  • [3] Stressing the role of a short linear motif in ataxin-2 condensation
    Scheidt, Tom
    Ruan, Hao
    Yu, Miao
    Lemke, Edward A.
    MOLECULAR CELL, 2023, 83 (12) : 1961 - 1963
  • [4] Conserved role for Ataxin-2 in mediating endoplasmic reticulum dynamics
    del Castillo, Urko
    Gnazzo, Megan M.
    Turpin, Christopher G. Sorensen
    Nguyen, Ken C. Q.
    Semaya, Emily
    Lam, Yuwan
    de Cruz, Matthew A.
    Bembenek, Joshua N.
    Hall, David H.
    Riggs, Blake
    Gelfand, Vladimir, I
    Skop, Ahna R.
    TRAFFIC, 2019, 20 (06) : 436 - 447
  • [5] Ataxin-2 Is Droppin' Some Knowledge
    Becker, Lindsay A.
    Gitler, Aaron D.
    NEURON, 2018, 98 (04) : 673 - 675
  • [6] Structural and functional analysis of ataxin-2 and ataxin-3
    Albrecht, M
    Golatta, M
    Wüllner, U
    Lengauer, T
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (15): : 3155 - 3170
  • [7] Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice
    Lastres-Becker, Isabel
    Brodesser, Susanne
    Luetjohann, Dieter
    Azizov, Mekhman
    Buchmann, Jana
    Hintermann, Edith
    Sandhoff, Konrad
    Schuermann, Annette
    Nowock, Joachim
    Auburger, Georg
    HUMAN MOLECULAR GENETICS, 2008, 17 (10) : 1465 - 1481
  • [8] Ataxin-2 associates with rough endoplasmic reticulum
    van de Loo, Simone
    Eich, Florian
    Nonis, David
    Auburger, Georg
    Nowock, Joachim
    EXPERIMENTAL NEUROLOGY, 2009, 215 (01) : 110 - 118
  • [9] Functional analysis of ataxin-2 domains in vitro
    Nguyen, DT
    Hiushan, NG
    Huynh, DP
    Stefan, PM
    NEUROLOGY, 2004, 62 (07) : A48 - A48
  • [10] Developmental role for ataxin-2 and the fox-1 homolog A2BP1.
    Kiehl, TR
    Nechiporuk, A
    Luthringer, DJ
    Pulst, SM
    AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (04) : 172 - 172