High-speed combinatorial synthesis utilizing microwave irradiation

被引：283

作者：

Kappe, CO ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, Inst Chem Organ & Bioorgan Chem, A-8010 Graz, Austria

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(02)00306-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances in microwave-assisted combinatorial chemistry include high-speed solid-phase and polymer-supported organic synthesis, rapid parallel synthesis of compound libraries, and library generation by automated sequential microwave irradiation. In addition, new instrumentation for high-throughput microwave-assisted synthesis continues to be developed at a steady pace. The impressive speed combined with the unmatched control over reaction parameters justifies the growing interest in this application of microwave heating.

引用

页码：314 / 320

页数：7

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